Phosphine-Catalyzed Synthesis of 1,3-Dihydro-3-alkylidene-2H-indol-2-ones

被引：1
|
作者：
Li Jingjie [1 ]
Wang Yuhao [1 ]
Meng Tiantian [1 ]
Huang Yiyong [1 ]
机构：
[1] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 42卷 / 07期
基金：
中国国家自然科学基金;
关键词：
indol-2-one; allene; phosphine catalysis; Michael addition; double bond migration; QUATERNARY CARBON CENTERS; ENANTIOSELECTIVE SYNTHESIS; TYROSINE KINASE; GAMMA; INHIBITORS; ALLENOATES; DISCOVERY; PRODUCTS; PROGRESS; DESIGN;
D O I：
10.6023/cjoc202201030
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A P(4-OMe-C6H4)(3)-catalyzed Michael addition/double bond migration tandem reaction between allenyl imide and indol-2-ones was developed. This synthetic strategy for diverse 1,3-dihydro-3-alkylidene-2H-indol-2-ones features operationally simple, good substrate scope, high chemoselectivity and mild reaction conditions. The proposed reaction mechanism is also provided.
引用
收藏
页码：2222 / 2228
页数：7
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