Asymmetric CuH-catalyzed hydrosilylations en route to the C-9 epimer of amphidinoketide I

被引：14

作者：

Lipshutz, Bruce H. ^{[1
]}

Lee, Ching-Tien ^{[1
]}

Servesko, Jeff M. ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 23期

关键词：

D O I：

10.1021/ol701999h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The C-9 diastereomer of amphidinoketide I has been synthesized. An asymmetric CuH-catalyzed hydrosilylation based on the Solvias nonracemic Josiphos-related ligand (RS)-PPF-P(t-BU)(2) was successfuliy used to introduce each of three stereocenters found in the target compound.

引用

页码：4713 / 4716

页数：4

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