In vitro resistance of clinical Fusarium species to amphotericin B and voriconazole using the EUCAST antifungal susceptibility method

被引：46

作者：

Taj-Aldeen, Saad J. ^{[1
,2
]}

Salah, Husam ^{[1
,3
]}

Al-Hatmi, Abdullah M. S. ^{[3
,4
,5
]}

Hamed, Manal ^{[1
]}

Theelen, Bart ^{[3
]}

van Diepeningen, Anne D. ^{[3
]}

Boekhout, Teun ^{[3
,6
,7
]}

Lass-Floerl, Cornelia ^{[8
]}

机构：

[1] Hamad Med Corp, Div Microbiol, Dept Lab Med & Pathol, POB 3050, Doha, Qatar

[2] Weill Cornell Med Coll, Doha, Qatar

[3] CBS KNAW Fungal Biodivers Ctr, Utrecht, Netherlands

[4] Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, Amsterdam, Netherlands

[5] Ibri Hosp, Minist Hlth, Directorate Gen Hlth Serv, Ibri, Oman

[6] Second Mil Med Univ, Changzheng Hosp, Inst Dermatol & Med Mycol, Dept Dermatol,Shanghai Key Lab Mol Med Mycol, Shanghai, Peoples R China

[7] Chinese Acad Sci, Inst Microbiol, Beijing, Peoples R China

[8] Med Univ Innsbruck, Div Hyg & Med Microbiol, Innsbruck, Austria

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2016年 / 85卷 / 04期

关键词：

Fusarium; EUCAST antifungal susceptibility; Amphotericin B; Triazoles; Resistance; CELL TRANSPLANT RECIPIENTS; INVASIVE FUSARIOSIS; PHYLOGENETIC DIVERSITY; FUNGAL-INFECTIONS; COMPLEX; DISEASES; SOLANI; SPP; LEUKEMIA; AGENTS;

D O I：

10.1016/j.diagmicrobio.2016.05.006

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Susceptibility testing using the EUCAST-AFST method against 39 clinical Fusarium strains consecutively collected from local and invasive infections during the last 10 years assessed the in vitro activities of amphotericin B (AmB) and triazole antifungal agents. In addition, the susceptibility pattern of 12 reference strains from the CBS-KNAW Fungal Biodiversity Centre (CBS) was evaluated. In particular Fusarium petroliphilum and F. solani sensu lato were involved in disseminated infections and known for treatment failure. AmB displayed the lowest MICs followed by voriconazole VRC, posaconazole (POC). Itraconazole (ITC) showed high MIC values, displaying in vitro resistance. Clinical isolates were significantly (P < 0.05) more resistant to AmB, VRC, and POC, than the CBS reference isolates probably due to previous exposure to antifungal therapy. Resistant profiles to AmB and VRC, which are the currently recommended agents in the guidelines for treatments, and a late diagnosis may be associated with high mortality rate in immunocompromised patients. The present antifungal susceptibility profiles showed that species- and strain-specific differences in antifungal susceptibility exist within Fusarium and that susceptibility testing is important and may improve the prognosis of these infections. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：438 / 443

页数：6

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