Accuracy of Screening Tests for Celiac Disease in Asymptomatic Patients With Type 1 Diabetes

被引：8

作者：

Gould, Michelle J. ^{[2
]}

Mahmud, Farid H. ^{[1
]}

Clarke, Antoine B. M. ^{[1
]}

McDonald, Charlotte ^{[3
]}

Saibil, Fred ^{[4
]}

Punthakee, Zubin ^{[5
]}

Marcon, Margaret A. ^{[2
]}

机构：

[1] Univ Toronto, Hosp Sick Children, Dept Pediat, Div Endocrinol, Toronto, ON, Canada

[2] Univ Toronto, Hosp Sick Children, Dept Pediat, Div Gastroenterol Hepatol & Nutr, Toronto, ON, Canada

[3] Western Univ, St Josephs Hlth Care London, Div Endocrinol & Metab, London, ON, Canada

[4] Univ Toronto, Sunnybrook Hlth Sci Ctr, Div Gastroenterol, Toronto, ON, Canada

[5] McMaster Univ, Div Endocrinol, Hamilton, ON, Canada

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 2021年 / 116卷 / 07期

关键词：

AT-RISK; PREVALENCE; CHILDREN;

D O I：

10.14309/ajg.0000000000001193

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

INTRODUCTION: To evaluate the diagnostic performance of celiac serologic tests in asymptomatic patients with type 1 diabetes (T1D). METHODS: Patients with T1D asymptomatic for celiac disease were prospectively screened with immunoglobulin A anti-tissue transglutaminase. Test characteristics were calculated and optimal cutoffs for a positive screen determined. RESULTS: Two thousand three hundred fifty-three patients were screened and 101 proceeded to biopsy. The positive predictive value of immunoglobulin A anti-tissue transglutaminase at the assay referenced upper limit of normal (30CU) was 85.9%, and the sensitivity and specificity were 100% and 38%, respectively. DISCUSSION: Thresholds extrapolated from the general population for the diagnostic evaluation of celiac disease are not suitable for use in asymptomatic T1D patients. Population-specific screening cutoffs are required.

引用

页码：1545 / 1549

页数：5

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