The synthesis and cytotoxic activity of novel organogermanium sesquioxides with anthraquinone or naphthalene moiety

被引：12
|
作者：
Shangguan, Guo Qiang [1 ]
Huang, Lun Liang
Qu, Xiao Gang
机构：
[1] Jining Med Coll, Dept Pharm, Rizhao 276826, Peoples R China
[2] Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Rare Earth Chem & Phys, Changchun 130022, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2007年 / 18卷 / 11期
关键词：
organogermanium sesquioxide; synthesis; cytotoxicity;
D O I：
10.1016/j.cclet.2007.09.029
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Four novel organogermanium sesquioxides with anthraquinone or naphthalene moiety were synthesized. The structures were characterized by IR, NMR and elemental analysis, and their cytotoxicities were evaluated against human chronic myeloid leukemia K562 cell lines. The cytotoxicity could be improved by the introduction of planar aromatic chromophore moiety to the parent compound, Ge-132. (c) 2007 Guo Qiang Shangguan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
引用
收藏
页码：1347 / 1350
页数：4
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