Antibacterial Hydrogel with Self-Healing Property for Wound-Healing Applications

被引：27

作者：

Bo, Yunyi ^{[1
]}

Zhang, Linhua ^{[2
]}

Wang, Zhifeng ^{[1
]}

Shen, Jiafu ^{[3
]}

Zhou, Ziwei ^{[1
]}

Yang, Yan ^{[1
]}

Wang, Yong ^{[4
]}

Qin, Jianglei ^{[3
]}

He, Yingna ^{[1
,5
]}

机构：

[1] Hebei Univ Chinese, Hebei Key Lab Chinese Med Res Cardio Cerebrovasc, Pharmaceut Coll, Shijiazhuang 050200, Hebei, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, Key Lab Biomed Mat Tianjin, Inst Biomed Engn, Tianjin 300192, Peoples R China

[3] Hebei Univ, Coll Chem & Environm Sci, Baoding 071002, Hebei, Peoples R China

[4] Hebei Univ, Key Lab Pathogenesis Mech & Control Inflammatory, Baoding 071002, Hebei, Peoples R China

[5] Res Ctr TCM Formula Preparat, Hebei Higher Educ Inst Appl Technol, Shijiazhuang 050200, Hebei, Peoples R China

来源：

ACS BIOMATERIALS SCIENCE & ENGINEERING | 2021年 / 7卷 / 11期

关键词：

self-healing hydrogel; antimicrobial property; wound healing sustained release; HEALABLE HYDROGELS; MULTIFUNCTIONAL HYDROGEL; COMPOSITE HYDROGEL;

D O I：

10.1021/acsbiomaterials.1c00719

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Hydrogels with inherent antibacterial ability are a focus in soft tissue repair. Herein, a series of antibacterial hydrogels were fabricated by quaternized N-[3-(dimethylamino)propyl] methacrylamide (quaternized P(DMAPMA-DMA-DAA)) bearing copolymers with dithiodipropionic acid dihydrazide (DTDPH) as cross-linker. The hydrogels presented efficient self-healing capability as well as a pH and redox-triggered gel-sol-gel transition property that is based on the dynamic acylhydrazone bond and disulfide linkage. Furthermore, the hydrogels showed good antibacterial activity, biocompatibility, degradability, and sustained release ability. More importantly, the in vivo experiments demonstrated that the hydrogels loaded with mouse epidermal growth factor (mEGF) significantly accelerated wound closure by preventing bacterial infection and promoting cutaneous regeneration in the wound model. The antibacterial hydrogels with self-healing behavior hold great potential in wound treatment.

引用

页码：5135 / 5143

页数：9

共 40 条

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