PACAP, VIP and their receptors in the metazoa: Insights about the origin and evolution of the ligand-receptor pair

被引：34
作者：
Cardoso, Joao C. R. [1 ]
Vieira, Florbela A. [1 ]
Gomes, Ana S. [1 ]
Power, Deborah M. [1 ]
机构：
[1] Univ Algarve, Ctr Marine Sci, P-8005 Faro, Portugal
来源：
PEPTIDES | 2007年 / 28卷 / 09期
基金：
美国国家科学基金会;
关键词：
evolution; GPCRs; ligand-receptor; metazoan; PACAP; VIP; PITUITARY ADENYLATE-CYCLASE; ACTIVATING POLYPEPTIDE PACAP; VASOACTIVE-INTESTINAL-PEPTIDE; HORMONE-RELEASING-HORMONE; PROTEIN-COUPLED RECEPTORS; FROG XENOPUS-LAEVIS; MOLECULAR-CLONING; SPLICE VARIANTS; I RECEPTOR; FUNCTIONAL EXPRESSION;
D O I：
10.1016/j.peptides.2007.05.016
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The evolution, function and interaction of ligand-receptor pairs are of major pharmaceutical interest. Comparative sequence analysis approaches using data from phylogenetically distant organisms can provide insights into their origin and possible physiological roles. The present review focuses on the pituitary adenylate cyclase-activating polypeptide (PACAP), vasoactive intestinal polypeptide (VIP) and their receptors in the metazoa. A PACAP-like peptide is present in tunicates and chordates while VIP- and PACAP/VIP-specific receptors have only been isolated in the latter phyla. The apparently disparate evolution of the ligands and their specific receptors raises questions about their evolution during the metazoan radiation and also about how the ligands may have acquired new functions. (C) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码：1902 / 1919
页数：18
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