A New and Practical Grignard-Coupling-Fluorination Sequence: Synthesis of 2-Aryl Fluoroarenes

被引：17
作者：
Anbarasan, Pazhamalai [1 ]
Neumann, Helfried [1 ]
Beller, Matthias [1 ]
机构：
[1] Univ Rostock, Katalyse eV, Leibniz Inst, D-18059 Rostock, Germany
来源：
CHEMISTRY-AN ASIAN JOURNAL | 2010年 / 5卷 / 08期
关键词：
arylfluorides; arynes; domino reactions; fluorination; Grignard reaction; ELECTROPHILIC FLUORINATION; FUNCTIONALIZED ARYL; EFFICIENT SYNTHESIS; HIGHLY EFFICIENT; REAGENTS; MAGNESIUM; SALTS; ARYLMAGNESIUM; SELECTFLUOR; ELIMINATION;
D O I：
10.1002/asia.201000288
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new strategy for the synthesis of 2-aryl-and 2-heteroaryl fluoroarenes has been developed. An intermolecular domino Grignard-coupling-fluorination sequence affords a range of 2-fluorobiaryls from aryl bromides under mild conditions. This methodology can be further extended to the synthesis of 2′-aryl-2-fluorobiphenyls. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：1775 / 1778
页数：4
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