Registries in rheumatological and musculoskeletal conditions. Paediatric Behcet's disease: an international cohort study of 110 patients. One-year follow-up data

被引:52
作者
Kone-Paut, Isabelle [1 ]
Darce-Bello, Martha [1 ]
Shahram, Farahd [2 ]
Gattorno, Marco [3 ]
Cimaz, Rolando [4 ]
Ozen, Seza [5 ]
Cantarini, Luca [6 ]
Tugal-Tutktun, Ilknur [7 ]
Assaad-Khalil, Samir [8 ]
Hofer, Michael [9 ]
Kuemmerle-Deschner, Jasmin [10 ]
Benamour, Saida [11 ]
Al Mayouf, Souleymane [12 ]
Pajot, Christine [13 ]
Anton, Jordi [14 ]
Faye, Albert [15 ]
Bono, Wafa [16 ]
Nielsen, Susan [17 ]
Letierce, Alexia [18 ]
Tran, Tu-Anh [1 ]
机构
[1] Paris SUD Univ Med, Bicetre Univ Hosp, CEREMAI, Dept Paediat Rheumatol, Le Kremlin Bicetre, France
[2] Shariati Hosp, Dept Rheumatol, Rheumatol Res Ctr, Tehran, Iran
[3] G Gaslini Sci Inst, UO Pediat 2, Genoa, Italy
[4] A Meyer Inst, Paediat Rheumatol Unit, Florence, Italy
[5] Hacettepe Univ, Dept Paediat, Ankara, Turkey
[6] Univ Siena, Dept Clin Med & Immunol Sci, Rheumatol Unit, I-53100 Siena, Italy
[7] Istanbul Univ, Istanbul Fac Med, Dept Ophthalmol, Istanbul, Turkey
[8] Alexandria Fac Med, Dept Internal Med, Alexandria, Egypt
[9] Vaudois Univ Hosp, Paediat Rheumatol Dept, Lausanne, Switzerland
[10] Univ Hosp, Div Pediat Rheumatol, Dept Pediat, Tubingen, Germany
[11] IBN Rochd Univ Hosp, Dept Internal Med, Casablanca, Morocco
[12] King Faisal Hosp Riyadh, Dept Paediat, Paediat Rheumatol Clin, Riyath, Saudi Arabia
[13] Toulouse Univ Hosp, Paediat Rheumatol Unit, Toulouse, France
[14] St Joan Deu Univ Hosp, Paediat Rheumatol Unit, Esplugas de Llobregat, Spain
[15] Robert Debre Univ Hosp, Dept Paediat, Paris, France
[16] Hassan II Univ Hosp, Internal Med & Immunol Clin, Fes, Morocco
[17] Paediat Clin, Copenhagen, Denmark
[18] Bicetre Univ Hosp, Clin Res Unit, Le Kremlin Bicetre, France
关键词
Pediatric Behcet's disease; Epidemiology; Cohort study; Definition of disease; Early-onset Behcet's disease; Outcome; CLINICAL-FEATURES; PREVALENCE;
D O I
10.1093/rheumatology/keq324
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Methods. International experts have defined the inclusion criteria as follows: recurrent oral aphthosis (ROA) plus one of following-genital ulceration, erythema nodosum, folliculitis, pustulous/acneiform lesions, positive pathergy test, uveitis, venous/arterial thrombosis and family history of BD. Onset of disease is < 16 years, disease duration is 3 years, future follow-up duration is epsilon 4 years and informed consent is obtained. The expert committee has classified the included patients into: definite paediatric BD (PED-BD), probable PED-BD and no PED-BD. Statistical analysis is performed to compare the three groups of patients. Centres document their patients into a single database. Results. At January 2010, 110 patients (56 males/54 females) have been included. Mean age at first symptom: 8.1 years (median 8.2 years). At inclusion, 38% had only one symptom associated with ROA, 31% had two and 31% had three or more symptoms. A total of 106 first evaluations have been done. Seventeen patients underwent the first-year evaluation, and 36 had no new symptoms, 12 had one and 9 had two. Experts have examined 48 files and classified 30 as definite and 18 as probable. Twenty-six patients classified as definite fulfilled the International Study Group criteria. Seventeen patients classified as probable did not meet the international criteria. Conclusion. The expert committee has classified the majority of patients in the BD group although they presented with few symptoms independently of BD classification criteria.
引用
收藏
页码:184 / 188
页数:5
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