Epicardium in Heart Development

被引：32
作者：
Cao, Yingxi [1 ]
Duca, Sierra [1 ]
Cao, Jingli [1 ]
机构：
[1] Cornell Univ, Weill Cornell Med Coll, Cardiovasc Res Inst, Dept Cell & Dev Biol, New York, NY 10021 USA
来源：
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2020年 / 12卷 / 02期
关键词：
REGULATE MYOCARDIAL PROLIFERATION; SMOOTH-MUSCLE; RETINOIC ACID; MESENCHYMAL TRANSFORMATION; CARDIOMYOCYTE PROLIFERATION; EXTRACELLULAR-MATRIX; CARDIAC FIBROBLASTS; CORONARY-ARTERY; ADIPOSE-TISSUE; PROGENITORS CONTRIBUTE;
D O I：
10.1101/cshperspect.a037192
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The epicardium, the outermost tissue layer that envelops all vertebrate hearts, plays a crucial role in cardiac development and regeneration and has been implicated in potential strategies for cardiac repair. The heterogenous cell population that composes the epicardium originates primarily from a transient embryonic cell cluster known as the proepicardial organ (PE). Characterized by its high cellular plasticity, the epicardium contributes to both heart development and regeneration in two critical ways: as a source of progenitor cells and as a critical signaling hub. Despite this knowledge, there are many unanswered questions in the field of epicardial biology, the resolution of which will advance the understanding of cardiac development and repair. We review current knowledge in cross-species epicardial involvement, specifically in relation to lineage specification and differentiation during cardiac development.
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页数：17
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