Serum Parathyroid Hormone, 25-Hydroxyvitamin D, and Risk of Alzheimer's Disease: A Mendelian Randomization Study

被引：32

作者：

Larsson, Susanna C. ^{[1
]}

Traylor, Matthew ^{[2
]}

Markus, Hugh S. ^{[2
]}

Michaelsson, Karl ^{[3
]}

机构：

[1] Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, SE-17177 Stockholm, Sweden

[2] Univ Cambridge, Dept Clin Neurosci, Stroke Res Grp, Cambridge, England

[3] Uppsala Univ, Dept Surg Sci, S-75105 Uppsala, Sweden

来源：

NUTRIENTS | 2018年 / 10卷 / 09期

关键词：

Alzheimer's disease; Mendelian randomization; parathyroid hormone; vitamin D; VITAMIN-D SUPPLEMENTATION; COGNITIVE IMPAIRMENT; VASCULAR DEMENTIA; INCIDENT DEMENTIA; GENETIC-VARIANTS; OLDER-ADULTS; BRAIN; METAANALYSIS; RECEPTOR; DENSITY;

D O I：

10.3390/nu10091243

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

We conducted Mendelian randomization analyses to investigate the associations of serum parathyroid hormone (S-PTH) and serum 25-hydroxyvitamin D (S-25OHD) concentrations with Alzheimer's disease (AD). Five and seven single nucleotide polymorphisms associated with S-PTH and S-25OHD concentrations, respectively, were used as instrumental variables. Data for AD were acquired from the International Genomics of Alzheimer's Project (17,008 AD cases and 37,154 controls). Genetically higher S-PTH concentrations were not associated with AD (odds ratio per standard deviation increase in S-PTH = 1.11; 95% CI 0.97-1.26; p = 0.12). In contrast, all seven 25OHD-increasing alleles were inversely associated with AD and two of the associations were statistically significant (p < 0.05). The odds ratio of AD per genetically-predicted one standard deviation increase in S-25OHD was 0.86 (95% CI 0.78-0.94; p = 0.002). This study provides evidence that vitamin D may play a role in AD but found no significant association between S-PTH and AD.

引用

页数：7

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