Differential p38 mitogen-activated protein kinase target phosphorylation in responders and nonresponders to infliximab

被引：31

作者：

Waetzig, GH ^{[1
]}

Rosenstiel, P ^{[1
]}

Nikolaus, S ^{[1
]}

Seegert, D ^{[1
]}

Schreiber, S ^{[1
]}

机构：

[1] Univ Kiel, Mucosal Immunol Grp, Dept Gen Internal Med, Med Ctr, Kiel, Germany

来源：

GASTROENTEROLOGY | 2003年 / 125卷 / 02期

关键词：

D O I：

10.1016/S0016-5085(03)00979-X

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

引用

页码：633 / 634

页数：2

共 6 条

[1] Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial [J].

Hanauer, SB ;

Feagan, BG ;

Lichtenstein, GR ;

Mayer, LF ;

Schreiber, S ;

Colombel, JF ;

Rachmilewitz, D ;

Wolf, DC ;

Olson, A ;

Bao, WH ;

Rutgeerts, P .

LANCET, 2002, 359 (9317) :1541-1549

[2] Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease [J].

Hommes, D ;

Van Den Blink, B ;

Plasse, T ;

Bartelsman, J ;

Xu, CP ;

MacPherson, B ;

Tytgat, G ;

Peppelenbosch, M ;

Van Deventer, S .

GASTROENTEROLOGY, 2002, 122 (01) :7-14

[3] Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway [J].

Lügering, A ;

Schmidt, M ;

Lügering, N ;

Pauels, HG ;

Domschke, W ;

Kucharzik, T .

GASTROENTEROLOGY, 2001, 121 (05) :1145-1157

[4] Mechanisms in failure of infliximab for Crohn's disease [J].

Nikolaus, S ;

Raedler, A ;

Kühbacher, T ;

Sfikas, N ;

Fölsch, UR ;

Schreiber, S .

LANCET, 2000, 356 (9240) :1475-1479

[5] Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease [J].

ten Hove, T ;

van Montfrans, C ;

Peppelenbosch, MP ;

van Deventer, SJH .

GUT, 2002, 50 (02) :206-211

[6] p38 mitogen-activated protein kinase is activated and linked to TNF-α signaling in inflammatory bowel disease [J].

Waetzig, GH ;

Seegert, D ;

Rosenstiel, P ;

Nikolaus, S ;

Schreiber, S .

JOURNAL OF IMMUNOLOGY, 2002, 168 (10) :5342-5351

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