Pancreatic Ductal Adenocarcinoma: Relating Biomechanics and Prognosis

被引：17

作者：

MacCurtain, Benjamin M. ^{[1
]}

Quirke, Ned P. ^{[2
]}

Thorpe, Stephen D. ^{[2
,3
]}

Gallagher, Tom K. ^{[1
]}

机构：

[1] St Vincents Univ Hosp, Dept Hepatobiliary & Transplant Surg, Dublin D04 T6F4, Ireland

[2] Univ Coll Dublin, UCD Sch Med, Dublin D04 V1W8, Ireland

[3] Univ Coll Dublin, UCD Conway Inst Biomol & Biomed Res, Dublin D04 V1W8, Ireland

来源：

JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 12期

关键词：

pancreatic cancer; pancreatic ductal adenocarcinoma (PDAC); neoadjuvant therapy; biomechanics; tissue mechanics; tumour microenvironment; extracellular matrix (ECM); elastography; endoscopic ultrasound; magnetic resonance elastography; ENDOSCOPIC ULTRASOUND ELASTOGRAPHY; MAGNETIC-RESONANCE ELASTOGRAPHY; CONTRAST-ENHANCED CT; VIRTUAL TOUCH QUANTIFICATION; CELL-MATRIX INTERACTIONS; SHEAR-WAVE ELASTOGRAPHY; EXTRACELLULAR-MATRIX; TISSUE TRANSGLUTAMINASE; TEXTURE ANALYSIS; NEOADJUVANT CHEMOTHERAPY;

D O I：

10.3390/jcm10122711

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer and carries a dismal prognosis. Resectable patients are treated predominantly with surgery while borderline resectable patients may receive neoadjuvant treatment (NAT) to downstage their disease prior to possible resection. PDAC tissue is stiffer than healthy pancreas, and tissue stiffness is associated with cancer progression. Another feature of PDAC is increased tissue heterogeneity. We postulate that tumour stiffness and heterogeneity may be used alongside currently employed diagnostics to better predict prognosis and response to treatment. In this review we summarise the biomechanical changes observed in PDAC, explore the factors behind these changes and describe the clinical consequences. We identify methods available for assessing PDAC biomechanics ex vivo and in vivo, outlining the relative merits of each. Finally, we discuss the potential use of radiological imaging for prognostic use.

引用

页数：17

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