Crystal structure of a yeast TFIIA/TBP/DNA complex

被引：258

作者：

Tan, S ^{[1
]}

Hunziker, Y ^{[1
]}

Sargent, DF ^{[1
]}

Richmond, TJ ^{[1
]}

机构：

[1] ETH HONGGERBERG,INST MOLEK BIOL & BIOPHYS,CH-8093 ZURICH,SWITZERLAND

来源：

NATURE | 1996年 / 381卷 / 6578期

关键词：

D O I：

10.1038/381127a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The X-ray crystal structure of the transcription factor IIA (TFIIA) in complex with the TATA-box-binding protein (TBP) and TATA-element DNA is presented at 2.5 Angstrom resolution. TFIIA is composed of a beta-barrel and a four-helix bundle motif that together have a boot-like appearance. The beta-barrel extends the TBP beta-sheet and bridges over the DNA major groove immediately upstream of the TATE box. The four-helix bundle contributes substantially to the surface of the complex available for interaction with additional transcription factors.

引用

页码：127 / 134

页数：8

共 50 条

[1]

[Anonymous], 1991, P CCP4 STUD WEEK IS

[2] AN ATP-DEPENDENT INHIBITOR OF TBP BINDING TO DNA [J].

AUBLE, DT ;

HAHN, S .

GENES & DEVELOPMENT, 1993, 7 (05) :844-856

[3]

BREATHNACH R, 1981, ANNU REV BIOCHEM, V50, P349, DOI 10.1146/annurev.bi.50.070181.002025

[4]

BRUNGER AT, 1992, XPLOR VERSION 3 1

[5] TRANSCRIPTION FACTOR-IID MUTANTS DEFECTIVE FOR INTERACTION WITH TRANSCRIPTION FACTOR-IIA [J].

BURATOWSKI, S ;

ZHOU, H .

SCIENCE, 1992, 255 (5048) :1130-1132

[6] 5 INTERMEDIATE COMPLEXES IN TRANSCRIPTION INITIATION BY RNA POLYMERASE-II [J].

BURATOWSKI, S ;

HAHN, S ;

GUARENTE, L ;

SHARP, PA .

CELL, 1989, 56 (04) :549-561

[7] CRYSTAL-STRUCTURE OF YEAST TATA-BINDING PROTEIN AND MODEL FOR INTERACTION WITH DNA [J].

CHASMAN, DI ;

FLAHERTY, KM ;

SHARP, PA ;

KORNBERG, RD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) :8174-8178

[8]

CONAWAY RC, 1993, ANNU REV BIOCHEM, V62, P161

[9] FACTORS INVOLVED IN SPECIFIC TRANSCRIPTION BY MAMMALIAN RNA POLYMERASE-II - PURIFICATION AND ANALYSIS OF TRANSCRIPTION FACTOR-IIA AND IDENTIFICATION OF TRANSCRIPTION FACTOR-IIJ [J].

CORTES, P ;

FLORES, O ;

REINBERG, D .

MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (01) :413-421

[10]

COULOMBE B, 1994, J BIOL CHEM, V269, P19962

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