Anxiety boosts progression of prediabetes to type 2 diabetes: findings from the prospective Cooperative Health Research in the Region of Augsburg F4 and FF4 studies

被引:18
作者
Jiang, L. [1 ,2 ,3 ]
Atasoy, S. [3 ,4 ,5 ]
Johar, H. [3 ,4 ,5 ]
Herder, C. [4 ,6 ,7 ]
Peters, A. [3 ,4 ]
Kruse, J. [5 ]
Ladwig, K-H [3 ,4 ,8 ]
机构
[1] Ludwig Maximilians Univ Munchen, Inst Med Informat Proc Biometry & Epidemiol IBE, Munich, Germany
[2] Pettenkofer Sch Publ Hlth, Munich, Germany
[3] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol, Neuherberg, Germany
[4] German Ctr Diabet Res DZD, Munich, Germany
[5] Univ Giessen & Marburg, Dept Psychosomat Med & Psychotherapy, Giessen, Germany
[6] Heinrich Heine Univ Dusseldorf, Med Fac, Div Endocrinol & Diabetol, Dusseldorf, Germany
[7] Heinrich Heine Univ Dusseldorf, German Diabet Ctr, Inst Clin Diabetol, Leibniz Ctr Diabet Res, Dusseldorf, Germany
[8] Tech Univ Munich, Dept Psychosomat Med & Psychotherapy, Klinikum Rechts Isar, Munich, Germany
关键词
DISORDER; RISK; MELLITUS;
D O I
10.1111/dme.14232
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aim To investigate the association between anxiety symptoms and the progression from prediabetes to type 2 diabetes. Methods A sample of 1708 participants aged 31-82 years from the population-based Cooperative Health Research in the Region of Augsburg F4 and the follow-up Cooperative Health Research in the Region of Augsburg FF4 studies was included. Prediabetes was defined as impaired fasting glucose and/or impaired glucose tolerance, and anxiety status was measured by the generalized anxiety disorder-7 questionnaire. Newly diagnosed type 2 diabetes cases were identified after 6.5 years (11 102 person-years) and confirmed by medical records. Multivariate logistic regression analyses were employed to estimate the effect of prediabetes and anxiety on the incidence of type 2 diabetes with different levels of adjustments for potential confounders. The population attributable risk of type 2 diabetes in participants with prediabetes and anxiety was estimated. Results Prediabetes at baseline was prevalent in 247 participants, of whom 77 developed diabetes after follow-up, accounting for a progression rate of 31%. In participants with prediabetes, high anxiety was associated with a 3-fold increased risk of progression to type 2 diabetes in comparison with low anxiety, even after accounting for socio-demographic, lifestyle and metabolic risk factors (OR = 2.82, 95% CI = 0.95-8.37, P = 0.06). A significant proportion of incident type 2 diabetes was attributed to having anxiety in addition to prediabetes (attributable risk proportion: 0.52; 95% CI = 0.004-1.04, P = 0.05). Conclusions Anxiety symptoms independently increase the progression risk of prediabetes to type 2 diabetes and should be routinely considered alongside the traditional risk factors in people with prediabetes.
引用
收藏
页码:1737 / 1741
页数:5
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