One-Pot Synthesis of Substituted Trifluoromethylated 2,3-Dihydro-1H-imidazoles

被引：7

作者：

Deutsch, Amrei ^{[1
]}

Jessen, Christoph ^{[1
]}

Deutsch, Carl ^{[2
]}

Karaghiosoff, Konstantin ^{[1
]}

Hoffmann-Roeder, Anja ^{[1
]}

机构：

[1] Univ Munich, Dept Chem, CIPSM, Butenandtstr 5-13, D-81377 Munich, Germany

[2] Merck KGaA, Med Chem, Frankfurter Str 250, D-64293 Darmstadt, Germany

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 14期

关键词：

LATE-STAGE FLUORINATION; DERIVATIVES; FLUORIDE; DESIGN;

D O I：

10.1021/acs.orglett.6b01672

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An operationally simple one-pot reaction for the preparation of a novel class of racemic trifluoromethylated 2,3dihydro-1H-imidazoles derived from electron-poor N,O-acetals and aryl Grignard reagents is described. In addition, access to highly functionalized 2-trifluoromethyl-2,3-dihydro-1H-imidazoles was accomplished by reaction of N-aryl hemiaminal ethers and N-aryl trifluoroethylamines in the presence of an excess of n-butyllithium.

引用

页码：3474 / 3477

页数：4

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