Effect of 1.2% of simvastatin gel as a local drug delivery system on Gingival Crevicular Fluid interleukin-6 & interleukin-8 levels in non surgical treatment of chronic periodontitis patients

被引:16
作者
Vemanaradhya, Gayathri Gunjiganur [1 ]
Emani, Shilpa [1 ]
Mehta, Dhoom Singh [1 ]
Bhandari, Shilpy [1 ]
机构
[1] Bapuji Dent Coll & Hosp, Dept Periodont, Davangere 577004, Karnataka, India
关键词
1.2% Simvastatin gel; IL-6; IL-8; Chronic periodontitis; Sub gingival local drug delivery; CONTROLLED CLINICAL-TRIAL; OSTEOBLAST DIFFERENTIATION; ADULT PERIODONTITIS; DISEASES; STATINS; CELLS; INFLAMMATION; CYTOKINES; RESPONSES; EFFICACY;
D O I
10.1016/j.archoralbio.2017.05.022
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Aim: The present study was carried out to evaluate the effect of 1.2% simvastatin gel as local drug delivery (LDD) system on Gingival Crevicular Fluid (GCF) Interleukin-6 (IL-6) and Interleukin-8 (IL-8) levels in chronic periodontitis patients, in addition to scaling and root planing (SRP). Methods: A total of 46 chronic periodontitis patients were equally divided into two groups. Group I patients were treated by SRP; Group II patients were treated by SRP followed by LDD of 1.2% simvastatin (SMV) gel. Plaque index (PI), Gingival index(GI), Sulcus Bleeding Index (SBI), Probing pocket depth (PPD) and Relative clinical attachment level (CAL) were recorded & GCF samples were collected at baseline (0 day) and at 45th day from both the groups. The collected GCF samples were analysed for IL-6 and IL-8 levels with enzyme-linked immunosorbent assay (ELISA). Results: Both the groups showed significant reduction in all the clinical parameters scores and IL-6 and IL-8 levels after non-surgical periodontal therapy (SRP for group I/SRP + 1.2% SMV gel for group II) in contrast to baseline values. However, a greater reduction was observed in group II. A non-significant positive correlation was observed between clinical parameters and IL-6 and IL-8 levels except at baseline, a significant correlation was observed between PPD & IL 6 levels in group II. Conclusions: In adjunct to SRP, 1.2% Simvastatin gel acts as an effective local drug delivery agent for the management of chronic periodontitis.
引用
收藏
页码:55 / 61
页数:7
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