Equilibrium studies on reactive extraction of naproxen enantiomers using hydrophilic β-cyclodetrin derivatives extractants

被引：6
作者：
Tang, Kewen [1 ]
Miao, Jiabing [2 ]
Zhou, Tao [2 ]
Song, Litao [2 ]
机构：
[1] Hunan Inst Sci & Technol, Dept Chem & Chem Engn, Yueyang 414006, Hunan, Peoples R China
[2] Cent S Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China
来源：
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2011年 / 69卷 / 1-2期
基金：
中国国家自然科学基金;
关键词：
Chiral separation; Reactive extraction; beta-Cyclodextrin derivatives; Naproxen enantiomers; RECOGNITION CHIRAL EXTRACTION; PERFORMANCE LIQUID-CHROMATOGRAPHY; CAPILLARY-ZONE-ELECTROPHORESIS; AMINO-ACIDS; ENANTIOSELECTIVE SEPARATION; STATIONARY PHASES; CYCLODEXTRIN; RESOLUTION; ELECTROCHROMATOGRAPHY; COMPLEXES;
D O I：
10.1007/s10847-010-9832-2
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A simple and low-cost method using liquid-liquid extraction coupled with complexation reactive technique has been developed for enantioselective separation of naproxen enantiomers. Three kinds of modified beta-cyclodextrins including methyl-beta-cyclodextrin (Me-beta-CD), hydroxyethyl-beta-cyclodextrin (HE-beta-CD) and hydroxypropyl-beta-cyclodextrin (HP-beta-CD), were selected as hydrophilic chiral selectors for extraction naproxen from organic phase to aqueous phase. A systematic study of the factors affecting chiral separation performance were investigated. The experiment results obtained show that, HP-beta-CD, HE-beta-CD and Me-beta-CD has stronger recognition abilities for S-naproxen than those for R-naproxen. Among the beta-CD derivatives studied, HP-beta-CD has the strongest ability for chiral recognition and separation. Excellent enantioselectivity (a) of 1.59 is obtained under the optimal conditions of pH of 2.5 and temperature of 5 A degrees C.
引用
收藏
页码：213 / 220
页数：8
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