Thyroid-state influence on protein-expression profile of rat skeletal muscle

被引：13
作者：
Silvestri, Elena
Burrone, Lavinia
de Lange, Pieter
Lombardi, Assunta
Farina, Paola
Chambery, Angela
Parente, Augusto
Lanni, Antonia
Goglia, Fernando
Moreno, Maria
机构：
[1] Univ Sannio, Dipartimento Sci Biol & Ambientali, I-82100 Benevento, Italy
[2] Seconda Univ Napoli, Dipartimento Sci Vita, I-81100 Caserta, Italy
[3] Univ Naples Federico 2, Sez Fisiol, Dipartimento Sci Biol, I-80134 Naples, Italy
来源：
JOURNAL OF PROTEOME RESEARCH | 2007年 / 6卷 / 08期
关键词：
triiodothyronine; rat gastrocnemius muscle; two-dimensional gel electrophoresis; HEAT-SHOCK PROTEINS; K-ATP CHANNELS; SMOOTH-MUSCLE; UNCOUPLING PROTEIN-3; SIGNAL-TRANSDUCTION; MASS-SPECTROMETRY; MAMMALIAN-CELLS; GENE-EXPRESSION; HORMONE ACTION; SOLEUS MUSCLE;
D O I：
10.1021/pr0701299
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
We analyzed the whole-cell protein content of gastrocnemius muscles from rats in different thyroid states. Twenty differentially expressed proteins were unambiguously identified. They were involved in substrates and energy metabolism, stress response, cell structure, and gene expression. This study represents the first systematic identification of thyroid state-induced changes in the skeletal muscle protein-expression profile and reveals new cellular pathways as targets for thyroid hormone action.
引用
收藏
页码：3187 / 3196
页数：10
相关论文
共 69 条
[1]   HSP27 phosphorylation and interaction with actin-myosin in smooth muscle contraction [J].
Bitar, KN .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2002, 282 (05) :G894-G903
[2]   Mapping of bovine skeletal muscle proteins using two-dimensional gel electrophoresis and mass spectrometry [J].
Bouley, J ;
Chambon, C ;
Picard, B .
PROTEOMICS, 2004, 4 (06) :1811-1824
[3]   INFLUENCE OF HYPERTHYROIDISM ON MAXIMAL SHORTENING VELOCITY AND MYOSIN ISOFORM DISTRIBUTION IN SKELETAL-MUSCLES [J].
CAIOZZO, VJ ;
HERRICK, RE ;
BALDWIN, KM .
AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 261 (02) :C285-C295
[4]   In vivo regulation of human skeletal muscle gene expression by thyroid hormone [J].
Clément, K ;
Viguerie, N ;
Diehn, M ;
Alizadeh, A ;
Barbe, P ;
Thalamas, C ;
Storey, JD ;
Brown, PO ;
Barsh, GS ;
Langin, D .
GENOME RESEARCH, 2002, 12 (02) :281-291
[5]   Nongenomic actions of thyroid hormone on the heart [J].
Davis, PJ ;
Davis, FB .
THYROID, 2002, 12 (06) :459-466
[6]   Uncoupling protein-3 is a molecular determinant for the regulation of resting metabolic rate by thyroid hormone [J].
de Lange, P ;
Lanni, A ;
Beneduce, L ;
Moreno, M ;
Lombardi, A ;
Silvestri, E ;
Goglia, F .
ENDOCRINOLOGY, 2001, 142 (08) :3414-3420
[7]   The glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase, triose-phosphate isomerase, and pyruvate kinase are components of the KATP channel macromolecular complex and regulate its function [J].
Dhar-Chowdhury, P ;
Harrell, MD ;
Han, SY ;
Jankowska, D ;
Parachuru, L ;
Morrissey, A ;
Srivastava, S ;
Liu, WX ;
Malester, B ;
Yoshida, H ;
Coetzee, WA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (46) :38464-38470
[8]   EFFECTS OF HYPOTHYROIDISM ON THE SENSITIVITY OF GLYCOLYSIS AND GLYCOGEN-SYNTHESIS TO INSULIN IN THE SOLEUS MUSCLE OF THE RAT [J].
DIMITRIADIS, GD ;
LEIGHTON, B ;
PARRYBILLINGS, M ;
WEST, D ;
NEWSHOLME, EA .
BIOCHEMICAL JOURNAL, 1989, 257 (02) :369-373
[9]   Thyroid hormone stimulates myoglobin expression in soleus and extensorum digitalis longus muscles of rats: Concomitant alterations in the activities of Krebs cycle oxidative enzymes [J].
dos Santos, RA ;
Giannocco, G ;
Nunes, MT .
THYROID, 2001, 11 (06) :545-550
[10]   Hsp20 and its cardioprotection [J].
Fan, GC ;
Chu, GX ;
Kranias, EG .
TRENDS IN CARDIOVASCULAR MEDICINE, 2005, 15 (04) :138-141
1234567