Emerging Role of Non-Coding RNAs in Senescence

被引：11

作者：

Ghafouri-Fard, Soudeh ^{[1
]}

Khoshbakht, Tayyebeh ^{[2
]}

Hussen, Bashdar Mahmud ^{[3
,4
]}

Baniahmad, Aria ^{[5
]}

Branicki, Wojciech ^{[6
]}

Taheri, Mohammad ^{[5
,7
]}

Eghbali, Ahmad ^{[8
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Sch Med, Dept Med Genet, Tehran, Iran

[2] Shahid Beheshti Univ Med Sci, Phytochemistry Res Ctr, Tehran, Iran

[3] Hawler Med Univ, Coll Pharm, Dept Pharmacognosy, Erbil, Iraq

[4] Lebanese French Univ, Ctr Res, Strateg Studies, Erbil, Iraq

[5] Jena Univ Hosp, Inst Human Genet, Jena, Germany

[6] Jagiellonian Univ, Malopolska Ctr Biotechnol, Krakow, Poland

[7] Shahid Beheshti Univ Med Sci, Urol & Nephrol Res Ctr, Tehran, Iran

[8] Shahid Beheshti Univ Med Sci, Mofid Children Hosp, Anesthesiol Res Ctr, Tehran, Iran

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2022年 / 10卷

关键词：

lncRNA; miRNA; senescence; expression; biomarker; epigenetics; MESENCHYMAL STEM-CELLS; CATENIN SIGNALING PATHWAY; CELLULAR SENESCENCE; ENDOTHELIAL SENESCENCE; CARDIAC SENESCENCE; PROLIFERATION; MIR-34A; AXIS; RADIOSENSITIVITY; DYSFUNCTION;

D O I：

10.3389/fcell.2022.869011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Senescence is defined as a gradual weakening of functional features of a living organism. Cellular senescence is a process that is principally aimed to remove undesirable cells by prompting tissue remodeling. This process is also regarded as a defense mechanism induced by cellular damage. In the course of oncogenesis, senescence can limit tumor progression. However, senescence participates in the pathoetiology of several disorders such as fibrotic disorders, vascular disorders, diabetes, renal disorders and sarcopenia. Recent studies have revealed contribution of different classes of non-coding RNAs in the cellular senescence. Long non-coding RNAs, microRNAs and circular RNAs are three classes of these transcripts whose contributions in this process have been more investigated. In the current review, we summarize the available literature on the impact of these transcripts in the cellular senescence.

引用

页数：13

共 176 条

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