Inhibition of D-amino acid oxidase by alpha-keto acids analogs of amino acids

被引：14

作者：

Moreno, JA

Montes, FJ

Catalan, J

Galan, MA

机构：

[1] Department of Chemical Engineering, University of Salamanca, Salamanca

[2] Department of Chemical Engineering, University of Salamanca, 37008 Salamanca

来源：

ENZYME AND MICROBIAL TECHNOLOGY | 1996年 / 18卷 / 05期

关键词：

D-amino acid oxidase; inhibition; alpha-keto acids;

D O I：

10.1016/0141-0229(95)00138-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The inhibition D-amino acid oxidase by certain alpha-keto acids products of the reaction with D-amino acids, in particular oc-keto acids that are analogs of the amino acids alanine, valine, leucine, phenylanaline, phenylglycine, tyrosine and tryptophan, is reported All the alpha-keto acids assayed behaved as substrate competitive inhibitors of the enzyme. The relationship between the degree of inhibition and the structure of the inhibitor is discussed.

引用

页码：379 / 382

页数：4

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