Inhibition of D-amino acid oxidase by alpha-keto acids analogs of amino acids

被引：14
|
作者：
Moreno, JA
Montes, FJ
Catalan, J
Galan, MA
机构：
[1] Department of Chemical Engineering, University of Salamanca, Salamanca
[2] Department of Chemical Engineering, University of Salamanca, 37008 Salamanca
来源：
ENZYME AND MICROBIAL TECHNOLOGY | 1996年 / 18卷 / 05期
关键词：
D-amino acid oxidase; inhibition; alpha-keto acids;
D O I：
10.1016/0141-0229(95)00138-7
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The inhibition D-amino acid oxidase by certain alpha-keto acids products of the reaction with D-amino acids, in particular oc-keto acids that are analogs of the amino acids alanine, valine, leucine, phenylanaline, phenylglycine, tyrosine and tryptophan, is reported All the alpha-keto acids assayed behaved as substrate competitive inhibitors of the enzyme. The relationship between the degree of inhibition and the structure of the inhibitor is discussed.
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页码：379 / 382
页数：4
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