Combined effects of curcumin and piperine in ameliorating benzo(a)pyrene induced DNA damage

被引：46

作者：

Sehgal, A. ^{[2
]}

Kumar, M. ^{[2
]}

Jain, M. ^{[2
]}

Dhawan, D. K. ^{[1
]}

机构：

[1] Panjab Univ, Dept Biophys, Chandigarh 160014, India

[2] Panjab Univ, Dept Zool, Chandigarh 160014, India

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2011年 / 49卷 / 11期

关键词：

Curcumin; Piperine; Benzo(a)pyrene; Genoprotective; POLYCYCLIC AROMATIC-HYDROCARBONS; BENZO<A>PYRENE DIOL EPOXIDES; COMET ASSAY; IN-VITRO; INDUCED MUTAGENICITY; SMALL-INTESTINE; TEA POLYPHENOL; STRAND BREAKS; HUMAN-CELLS; INHIBITION;

D O I：

10.1016/j.fct.2011.07.058

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The present study was planned to investigate the antigenotoxic effects of curcumin and piperine separately and in combination against benzo(a)pyrene (BaP) induced DNA damage in lungs and livers of mice. Male Swiss albino mice received curcumin (100 mg kg(-1) body weight) and piperine (20 mg kg(-1) body weight) separately as well as in combination orally in corn oil for 7 days as pretreatments and subsequently, 2 h after. BaP was administered orally in corn oil (125 mg kg(-1) body weight). A single dose of BaP to normal mice increased the level of 8-oxo-2'-deoxyguanosine (8-oxo-dG) content and % DNA in the comet tail in the lungs and liver. Pretreatments of curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of 8-oxo-dG content and % DNA in the comet tail in both the tissues. Moreover, the genoprotective potential of curcumin plus piperine was significantly higher as compared to curcumin alone against BaP induced DNA damage. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：3002 / 3006

页数：5

共 58 条

[21] Glutathione S-transferase A1-1-catalysed conjugation of bay and fjord region diol epoxides of polycyclic aromatic hydrocarbons with glutathione [J].