Heralding Healthcare Professionals: Recognition of Neurological Deficits in COVID-19

被引:6
作者
Baig, Abdul Mannan [1 ]
Sanders, Erin C. [2 ]
机构
[1] Aga Khan Univ, Dept Biol & Biomed Sci, Karachi 74800, Pakistan
[2] Mt Auburn Hosp, Boston Urogynecol Associates, Cambridge, MA 02138 USA
来源
ACS CHEMICAL NEUROSCIENCE | 2020年 / 11卷 / 12期
关键词
COVID-19; SARS-CoV-2; healthcare in COVID-19; anosmia; ACE2; neurovirulence SARS-CoV-2;
D O I
10.1021/acschemneuro.0c00286
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The 2019 novel coronavirus disease (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a zoonotic disease that is dominated by pulmonary symptoms. However, recent reports of isolation of the virus from cerebrospinal fluid (CSF) coupled with radiological evidence of zones of necrosis in the brain, have elucidated the neurotropic potential of SARS-CoV-2. The acute respiratory failure seen in patients with COVID-19 is alarming and could be due to the effects of SARS-CoV-2 on the central respiratory regulatory centers in the brainstem. Appropriate interventions can be implemented to prevent severe outcomes of neurological invasion by SARS-CoV-2 to reduce the morbidity and mortality of patients with COVID19. It is of paramount importance that the scientific community alerts the healthcare professionals of the pieces of evidence that can herald them on the covert neurological deficits in progress in COVID-19.
引用
收藏
页码:1701 / 1703
页数:3
相关论文
共 9 条
  • [1] [Anonymous], ANO NEW COVID 19 AN
  • [2] Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms
    Baig, Abdul Mannan
    Khaleeq, Areeba
    Ali, Usman
    Syeda, Hira
    [J]. ACS CHEMICAL NEUROSCIENCE, 2020, 11 (07): : 995 - 998
  • [3] Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
    Chen, Nanshan
    Zhou, Min
    Dong, Xuan
    Qu, Jieming
    Gong, Fengyun
    Han, Yang
    Qiu, Yang
    Wang, Jingli
    Liu, Ying
    Wei, Yuan
    Xia, Jia'an
    Yu, Ting
    Zhang, Xinxin
    Zhang, Li
    [J]. LANCET, 2020, 395 (10223) : 507 - 513
  • [4] Chen S, 2020, JAMA Neurol, DOI [10.1101/2020.02.22.20026500, 10.1001/jamaneurol.2020.1127]
  • [5] Sudden and Complete Olfactory Loss of Function as a Possible Symptom of COVID-19
    Eliezer, Michael
    Hautefort, Charlotte
    Hamel, Anne-Laure
    Verillaud, Benjamin
    Herman, Philippe
    Houdart, Emmanuel
    Eloit, Corinne
    [J]. JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY, 2020, 146 (07) : 674 - 675
  • [6] The clinical feature of silent infections of novel coronavirus infection (COVID-19) in Wenzhou
    He, Guiqing
    Sun, Wenjie
    Fang, Peipei
    Huang, Jianping
    Gamber, Michelle
    Cai, Jing
    Wu, Jing
    [J]. JOURNAL OF MEDICAL VIROLOGY, 2020, 92 (10) : 1761 - 1763
  • [7] The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients
    Li, Yan-Chao
    Bai, Wan-Zhu
    Hashikawa, Tsutomu
    [J]. JOURNAL OF MEDICAL VIROLOGY, 2020, 92 (06) : 552 - 555
  • [8] COVID-19-associated Acute Hemorrhagic Necrotizing Encephalopathy: Imaging Features
    Poyiadji, Neo
    Shahin, Gassan
    Noujaim, Daniel
    Stone, Michael
    Patel, Suresh
    Griffith, Brent
    [J]. RADIOLOGY, 2020, 296 (02) : E119 - E120
  • [9] Zhou L, 2020, TRAVEL MED INFECT DI, DOI [10.1016/j.tmaid.2020.101642, DOI 10.1016/J.TMAID.2020.101642]