Periostin and Interleukin-13 Are Independently Related to Chronic Spontaneous Urticaria

被引：24

作者：

Bae, Youin ^{[1
]}

Izuhara, Kenji ^{[2
]}

Ohta, Soichiro ^{[3
]}

Ono, Junya ^{[4
]}

Hong, Gwan Ui ^{[5
,6
]}

Ro, Jai Youl ^{[5
,6
]}

Park, Gyeong Hun ^{[1
]}

Choi, Jeong-Hee ^{[7
]}

机构：

[1] Hallym Univ, Dongtan Sacred Heart Hosp, Dept Dermatol, Hwaseong, South Korea

[2] Saga Med Sch, Dept Biomol Sci, Div Med Biochem, Saga, Japan

[3] Saga Med Sch, Dept Lab Med, Saga, Japan

[4] Shino Test Corp, Sagamihara, Kanagawa, Japan

[5] Sungkyunkwan Univ, Dept Pharmacol, Sch Med, Suwon, South Korea

[6] Sungkyunkwan Univ, SBRI, Sch Med, Suwon, South Korea

[7] Hallym Univ, Dept Pulmonol & Allergy, Dongtan Sacred Heart Hosp, 7 Keunjaebong Gil, Hwaseong 18450, South Korea

来源：

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | 2016年 / 8卷 / 05期

关键词：

Urticaria; periostin; interleukin-13; CHRONIC IDIOPATHIC URTICARIA; ALLERGIC INFLAMMATION; CYTOKINES; HISTAMINE; IL-13;

D O I：

10.4168/aair.2016.8.5.457

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Chronic spontaneous urticaria (CSU) is a complex idiopathic disease of the skin with various cellular infiltrations. Although mast cells are key effector cells in the pathogenesis of CSU, CD4+ T helper 2 cells also have particular roles in the development and maintenance of CSU. Periostin is known as a downstream molecule of interleukin (IL)-4 and IL-13, key cytokines of type 2 immune responses. In this study, we examined periostin and IL-13 levels in the sera of patients with CSU (n=84) and healthy normal controls (NCs, n=43). Periostin levels were significantly lower in the CSU group than in NCs (71.4 +/- 21.8 vs 85.1 +/- 22.4 ng/mL, P=0.04). Periostin levels were also lower in the severe CSU group than those in mild CSU (59.7 +/- 18.0 vs 73.4 +/- 22.0 ng/mL, P=0.04). However, IL-13 levels were significantly higher in patients with CSU than in NCs (508.5 +/- 51.2 vs 200.7 +/- 13.3 pg/mL, P=0.001). In conclusion, periostin and IL-13 may be independently related to the pathogenesis of CSU.

引用

页码：457 / 460

页数：4

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