Reactions of the Blood System and Stem Cells in Bleomycin-Induced Model of Lung Fibrosis

被引：8

作者：

Dygai, A. M. ^{[1
]}

Skurikhin, E. G. ^{[1
]}

Andreeva, T. V. ^{[1
]}

Ermolaeva, L. A. ^{[1
]}

Khmelevskaya, E. S. ^{[1
]}

Pershina, O. V. ^{[1
]}

Krupin, V. A. ^{[1
]}

Reztsova, A. M. ^{[1
]}

Stepanova, I. E. ^{[1
]}

Goldberg, V. E. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Siberian Div, Tomsk Res Ctr, Inst Pharmacol, Tomsk 109801, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2011年 / 152卷 / 02期

关键词：

pulmonary fibrosis; hemopoiesis; stem cells; committed hemopoietic and stromal progenitor cells;

D O I：

10.1007/s10517-011-1480-z

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

On the model of toxic diffuse pulmonary fibrosis induced by intratracheal administration of bleomycin, we studied reactions of the blood system, content of stem cells, committed hemopoietic and stromal progenitor cells in the bone marrow, spleen and peripheral blood of C57Bl/6 mice. It was shown that the development of diffuse pulmonary fibrosis was accompanied by hyperplasia of bone marrow hemopoiesis and leukocytosis in the peripheral blood. Activation of the erythroid and granulocytic hemopoietic stems was related to stimulation of hemopoietic stem cells (polypotent cells, granulocyte/erythroid/macrophage/megakaryocyte precursor cells) and committed erythroid and myeloid progenitor cells in the bone marrow. At the same time, the number of stromal precursors increased. Bleomycin increased the count of hemopoietic stem cells the peripheral blood and spleen and reduced the content of mesenchymal stem cells in the spleen and bone marrow.

引用

页码：173 / 176

页数：4

共 11 条

[1]

DYGAI AM, 2010, B EKSP BIOL MED, V148, P400

[2]

Goldberg E. D., 1992, METHODS TISSUE CULTU

[3]

GOLDBERG ED, 2007, PHARM REGULATION BLO

[4]

ILKOVICH MM, 1969, INTERSTITIAL LUNG DI, P127

[5] Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues [J].

Massberg, Steffen ;

Schaerli, Patrick ;

Knezevic-Maramica, Irina ;

Koellnberger, Maria ;

Tubo, Noah ;

Moseman, E. Ashley ;

Huff, Ines V. ;

Junt, Tobias ;

Wagers, Amy J. ;

Mazo, Irina B. ;

von Andrian, Ulrich H. .

CELL, 2007, 131 (05) :994-1008

[6]

Merkulov G.V., 1969, COURSE HISTOPATHOLOG

[7] Human Umbilical Cord Mesenchymal Stem Cells Reduce Fibrosis of Bleomycin-Induced Lung Injury [J].

Moodley, Yuben ;

Atienza, Daniel ;

Manuelpillai, Ursula ;

Samuel, Chrishan S. ;

Tchongue, Jorge ;

Ilancheran, Sivakami ;

Boyd, Richard ;

Trounson, Alan .

AMERICAN JOURNAL OF PATHOLOGY, 2009, 175 (01) :303-313

[8]

[Новикова Л.Н. Novikova L.N.], 2008, [Пульмонология, Pul'monologiya], P82

[9] Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects [J].

Ortiz, LA ;

Gambelli, F ;

McBride, C ;

Gaupp, D ;

Baddoo, M ;

Kaminski, N ;

Phinney, DG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (14) :8407-8411

[10] Bone marrow-derived mesenchymal stem cells in repair of the injured lung [J].

Rojas, M ;

Xu, JG ;

Woods, CR ;

Mora, AL ;

Spears, W ;

Roman, J ;

Brigham, KL .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2005, 33 (02) :145-152

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