Rhodium-catalyzed chemo-, regio-, and enantioselective [2+2+2] cycloaddition of alkynes with isocyanates

被引：121
作者：
Tanaka, K [1 ]
Wada, A
Noguchi, K
机构：
[1] Tokyo Univ Agr & Technol, Dept Appl Chem, Grad Sch Engn, Koganei, Tokyo 1848588, Japan
[2] Tokyo Univ Agr & Technol, Instrumentat Anal Ctr, Koganei, Tokyo 1848588, Japan
来源：
ORGANIC LETTERS | 2005年 / 7卷 / 21期
关键词：
D O I：
10.1021/ol052041b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We have developed a cationic rhodium([)/modified-BINAP complex-catalyzed chemoselective [2 + 2 + 2] cycloaddition of alkynes with isocyanates leading to a wide range of 2-pyridones. This method was successfully applied to the chemo-, regio-, and enantioselective synthesis of axially chiral 2-pyridones from unsymmetrical alpha,omega,-diynes, bearing an ortho-substituted phenyl at one terminal position, and alkyl isocyanates.
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页码：4737 / 4739
页数：3
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