Inhibitory effects of costunolide on the telomerase activity in human breast carcinoma cells

被引：55

作者：

Choi, SH

Im, E

Kang, HK

Lee, JH

Kwak, HS

Bae, YT

Park, HJ

Kim, ND ^{[1
]}

机构：

[1] Pusan Natl Univ, Coll Pharm, Dept Pharm, Pusan 609735, South Korea

[2] Pusan Natl Univ, Res Inst Drug Dev, Pusan 609735, South Korea

[3] Pusan Natl Univ, Coll Med, Dept Surg, Pusan 602739, South Korea

[4] Sangji Univ, Div Appl Plant Sci, Wonju 220702, South Korea

来源：

CANCER LETTERS | 2005年 / 227卷 / 02期

关键词：

costunolide; telomerase; hTERT; breast cancer; c-Myc; Sp1;

D O I：

10.1016/j.canlet.2005.01.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Costunolide, a natural sesquiterpene compound, has been known having cytotoxic and chemopreventive effects on various human cancer cells. In the present study, we examined the effects of costunolide on telomerase activity and on the components of telomerase in MCF-7 (wild-type p53) and MDA-MB-231 (mutant p53) cells. We found that costunolide inhibited the growth and telomerase activity of MCF-7 and MDA-MB-231 cells in a concentration- and time-dependent manner. The expression of hTERT mRNA was also inhibited but hTR mRNA was not. In addition, the bindings of transcription factors in hTERT promoters were significantly decreased in both cells by the treatment of costunolide. These results suggest that costunolide inhibited the growth of both MCF-7 and MDA-MB-231 cells and this effect was mediated at least in part by a significant reduction in telomerase activity. (C) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：153 / 162

页数：10

共 64 条

[1]

Aldous WK, 1999, CANCER, V85, P1523, DOI 10.1002/(SICI)1097-0142(19990401)85:7<1523::AID-CNCR13>3.3.CO

[2]

2-G

[3] A sesquiterpene lactone, costunolide, interacts with microtubule protein and inhibits the growth of MCF-7 cells [J].