The biology and mathematical modelling of glioma invasion: a review

被引：156

作者：

Alfonso, J. C. L. ^{[1
,2
,3
]}

Talkenberger, K. ^{[3
]}

Seifert, M. ^{[4
,6
]}

Klink, B. ^{[5
,6
,7
,8
]}

Hawkins-Daarud, A. ^{[9
]}

Swanson, K. R. ^{[9
]}

Hatzikirou, H. ^{[1
,2
,3
]}

Deutsch, A. ^{[3
]}

机构：

[1] Helmholtz Ctr Infect Res, Dept Syst Immunol, Braunschweig, Germany

[2] Helmholtz Ctr Infect Res, Braunschweig Integrated Ctr Syst Biol, Braunschweig, Germany

[3] Tech Univ Dresden, Fac Med Carl Gustav Carus, Ctr Informat Serv & High Performance Comp, Dresden, Germany

[4] Tech Univ Dresden, Fac Med Carl Gustav Carus, Inst Med Informat & Biometry, Dresden, Germany

[5] Tech Univ Dresden, Fac Med Carl Gustav Carus, Inst Clin Genet, Dresden, Germany

[6] Natl Ctr Tumor Dis NCT, Dresden, Germany

[7] German Canc Consortium DKTK, Partner Site, Dresden, Germany

[8] German Canc Res Ctr, Heidelberg, Germany

[9] Mayo Clin, Precis Neurotherapeut Innovat Program, Phoenix, AZ USA

来源：

JOURNAL OF THE ROYAL SOCIETY INTERFACE | 2017年 / 14卷 / 136期

基金：

美国国家卫生研究院;

关键词：

glioma invasion; cell phenotypic plasticity; malignant progression; infiltrative tumour morphology; mathematical modelling; ADVANCED MRI TECHNIQUES; PHASE-II TRIAL; MALIGNANT GLIOMAS; GLIOBLASTOMA-MULTIFORME; TUMOR HETEROGENEITY; GROWTH-FACTOR; IN-SILICO; INTRATUMOR HETEROGENEITY; GLUCOSE-METABOLISM; NERVOUS-SYSTEM;

D O I：

10.1098/rsif.2017.0490

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Adult gliomas are aggressive brain tumours associated with low patient survival rates and limited life expectancy. The most important hallmark of this type of tumour is its invasive behaviour, characterized by a markedly phenotypic plasticity, infiltrative tumour morphologies and the ability of malignant progression from low-to high-grade tumour types. Indeed, the widespread infiltration of healthy brain tissue by glioma cells is largely responsible for poor prognosis and the difficulty of finding curative therapies. Meanwhile, mathematical models have been established to analyse potential mechanisms of glioma invasion. In this review, we start with a brief introduction to current biological knowledge about glioma invasion, and then critically review and highlight future challenges for mathematical models of glioma invasion.

引用

页数：20

共 210 条

[1] Astrocyte-endothelial interactions at the blood-brain barrier [J].

Abbott, NJ ;

Rönnbäck, L ;

Hansson, E .

NATURE REVIEWS NEUROSCIENCE, 2006, 7 (01) :41-53

[2] Comprehensive molecular characterization of multifocal glioblastoma proves its monoclonal origin and reveals novel insights into clonal evolution and heterogeneity of glioblastomas [J].

Abou-El-Ardat, Khalil ;

Seifert, Michael ;

Becker, Kerstin ;

Eisenreich, Sophie ;

Lehmann, Matthias ;

Hackmann, Karl ;

Rump, Andreas ;

Meijer, Gerrit ;

Carvalho, Beatriz ;

Temme, Achim ;

Schackert, Gabriele ;

Schroeck, Evelin ;

Krex, Dietmar ;

Klink, Barbara .

NEURO-ONCOLOGY, 2017, 19 (04) :546-557

[3] The genome sequence of Drosophila melanogaster [J].

Adams, MD ;

Celniker, SE ;

Holt, RA ;

Evans, CA ;

Gocayne, JD ;

Amanatides, PG ;

Scherer, SE ;

Li, PW ;

Hoskins, RA ;

Galle, RF ;

George, RA ;

Lewis, SE ;

Richards, S ;

Ashburner, M ;

Henderson, SN ;

Sutton, GG ;

Wortman, JR ;

Yandell, MD ;

Zhang, Q ;

Chen, LX ;

Brandon, RC ;

Rogers, YHC ;

Blazej, RG ;

Champe, M ;

Pfeiffer, BD ;

Wan, KH ;

Doyle, C ;

Baxter, EG ;

Helt, G ;

Nelson, CR ;

Miklos, GLG ;

Abril, JF ;

Agbayani, A ;

An, HJ ;

Andrews-Pfannkoch, C ;

Baldwin, D ;

Ballew, RM ;

Basu, A ;

Baxendale, J ;

Bayraktaroglu, L ;

Beasley, EM ;

Beeson, KY ;

Benos, PV ;

Berman, BP ;

Bhandari, D ;

Bolshakov, S ;

Borkova, D ;

Botchan, MR ;

Bouck, J ;

Brokstein, P .

SCIENCE, 2000, 287 (5461) :2185-2195

[4] Magnetic resonance imaging with hyperpolarized agents: methods and applications [J].

Adamson, Erin B. ;

Ludwig, Kai D. ;

Mummy, David G. ;

Fain, Sean B. .

PHYSICS IN MEDICINE AND BIOLOGY, 2017, 62 (13) :R81-R123

[5] Function of the Blood-Brain Barrier and Restriction of Drug Delivery to Invasive Glioma Cells: Findings in an Orthotopic Rat Xenograft Model of Glioma [J].

Agarwal, Sagar ;

Manchanda, Pooja ;

Vogelbaum, Michael A. ;

Ohlfest, John R. ;

Elmquist, William F. .

DRUG METABOLISM AND DISPOSITION, 2013, 41 (01) :33-39

[6] Pediatric and adult glioblastoma radiosensitization induced by PI3K/mTOR inhibition causes early metabolic alterations detected by nuclear magnetic resonance spectroscopy [J].

Agliano, Alice ;

Balarajah, Geetha ;

Ciobota, Daniela M. ;

Sidhu, Jasmin ;

Clarke, Paul A. ;

Jones, Chris ;

Workman, Paul ;

Leach, Martin O. ;

Al-Saffar, Nada M. S. .

ONCOTARGET, 2017, 8 (29) :47969-47983

[7] Why one-size-fits-all vaso-modulatory interventions fail to control glioma invasion: in silico insights [J].

Alfonso, J. C. L. ;

Koehn-Luque, A. ;

Stylianopoulos, T. ;

Feuerhake, F. ;

Deutsch, A. ;

Hatzikirou, H. .

SCIENTIFIC REPORTS, 2016, 6

[8] Selecting Radiotherapy Dose Distributions by Means of Constrained Optimization Problems [J].

Alfonso, J. C. L. ;

Buttazzo, G. ;

Garcia-Archilla, B. ;

Herrero, M. A. ;

Nunez, L. .

BULLETIN OF MATHEMATICAL BIOLOGY, 2014, 76 (05) :1017-1044

[9] The inflammatory micro-environment in tumor progression: The role of tumor-associated macrophages [J].

Allavena, Paola ;

Sica, Antonio ;

Solinas, Graziella ;

Porta, Chiara ;

Mantovani, Alberto .

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2008, 66 (01) :1-9

[10] The mathematics of cancer: integrating quantitative models [J].

Altrock, Philipp M. ;

Liu, Lin L. ;

Michor, Franziska .

NATURE REVIEWS CANCER, 2015, 15 (12) :730-745

← 1 2 3 4 5 6 7 8 9 10 →