Anti-HCV, nucleotide inhibitors, repurposing against COVID-19

被引：475
作者：
Elfiky, Abdo A. [1 ,2 ]
机构：
[1] Cairo Univ, Fac Sci, Biophys Dept, Giza, Egypt
[2] Univ Al Jouf, Coll Appl Med Sci, Sakakah, Saudi Arabia
来源：
LIFE SCIENCES | 2020年 / 248卷
关键词：
Wuhan coronavirus; COVID-19; RdRp; Docking; Structural bioinformatics; Sofosbuvir; Nucleotide inhibitors; HEPATITIS-C; ANTIVIRAL ACTIVITY; PLUS RIBAVIRIN; POLYMERASE; SOFOSBUVIR; DOCKING; VIRUS; IDX-184; DRUGS; OPTIMIZATION;
D O I：
10.1016/j.lfs.2020.117477
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aims: A newly emerged Human Coronavirus (HCoV) is reported two months ago in Wuhan, China (COVID-19). Until today > 2700 deaths from the 80,000 confirmed cases reported mainly in China and 40 other countries. Human to human transmission is confirmed for COVID-19 by China a month ago. Based on the World Health Organization (WHO) reports, SARS HCoV is responsible for > 8000 cases with confirmed 774 deaths. Additionally, MERS HCoV is responsible for 858 deaths out of about 2500 reported cases. The current study aims to test anti-HCV drugs against COVID-19 RNA dependent RNA polymerase (RdRp). Materials and methods: In this study, sequence analysis, modeling, and docking are used to build a model for Wuhan COVID-19 RdRp. Additionally, the newly emerged Wuhan HCoV RdRp model is targeted by anti-polymerase drugs, including the approved drugs Sofosbuvir and Ribavirin. Key findings: The results suggest the effectiveness of Sofosbuvir, IDX-184, Ribavirin, and Remidisvir as potent drugs against the newly emerged HCoV disease. Significance: The present study presents a perfect model for COVID-19 RdRp enabling its testing in silico against anti-polymerase drugs. Besides, the study presents some drugs that previously proved its efficiency against the newly emerged viral infection.
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页数：6
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