Prostate Cancer Susceptibility in Men of African Ancestry at 8q24

被引：94

作者：

Han, Ying ^{[1
]}

Rand, Kristin A. ^{[1
]}

Hazelett, Dennis J. ^{[1
]}

Ingles, Sue A. ^{[1
,3
]}

Kittles, Rick A. ^{[4
,5
]}

Strom, Sara S. ^{[6
]}

Rybicki, Benjamin A. ^{[8
]}

Nemesure, Barbara ^{[10
]}

Isaacs, William B. ^{[11
]}

Stanford, Janet L. ^{[12
,14
]}

Zheng, Wei ^{[15
]}

Schumacher, Fredrick R. ^{[1
,3
]}

Berndt, Sonja I. ^{[16
]}

Wang, Zhaoming ^{[16
,17
]}

Xu, Jianfeng ^{[18
,19
]}

Rohland, Nadin ^{[20
,22
]}

Reich, David ^{[20
,21
,22
]}

Tandon, Arti ^{[20
,22
,29
]}

Pasaniuc, Bogdan ^{[23
,24
]}

Allen, Alex ^{[20
,22
]}

Quinque, Dominique ^{[20
,22
]}

Mallick, Swapan ^{[20
,21
,22
]}

Notani, Dimple ^{[25
]}

Rosenfeld, Michael G. ^{[25
]}

Jayani, Ranveer Singh ^{[25
]}

Kolb, Suzanne ^{[12
]}

Gapstur, Susan M. ^{[26
]}

Stevens, Victoria L. ^{[26
]}

Pettaway, Curtis A. ^{[7
]}

Yeboah, Edward D. ^{[27
,28
]}

Tettey, Yao ^{[27
,28
]}

Biritwum, Richard B. ^{[27
,28
]}

Adjei, Andrew A. ^{[27
,28
]}

Tay, Evelyn ^{[27
,28
]}

Truelove, Ann

Niwa, Shelley ^{[29
]}

Chokkalingam, Anand P. ^{[30
]}

John, Esther M. ^{[31
,32
,33
]}

Murphy, Adam B. ^{[34
]}

Signorello, Lisa B. ^{[35
]}

Carpten, John ^{[36
]}

Leske, M. Cristina ^{[10
]}

Wu, Suh-Yuh ^{[10
]}

Hennis, Anslem J. M. ^{[10
,37
,38
]}

Neslund-Dudas, Christine ^{[9
]}

Hsing, Ann W. ^{[31
,32
,33
]}

Chu, Lisa ^{[31
,32
,33
]}

Goodman, Phyllis J. ^{[13
]}

Klein, Eric A. ^{[39
]}

Zheng, S. Lilly ^{[40
]}

机构：

[1] Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90089 USA

[2] Univ Southern Calif, Keck Sch Med, Dept Urol, Los Angeles, CA 90089 USA

[3] Univ Southern Calif, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA

[4] Univ Arizona, Coll Med, Tucson, AZ 85724 USA

[5] Univ Arizona, Ctr Canc, Tucson, AZ 85724 USA

[6] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA

[7] Univ Texas MD Anderson Canc Ctr, Dept Urol, Houston, TX 77030 USA

[8] Henry Ford Hosp, Dept Publ Hlth Sci, Detroit, MI 48202 USA

[9] Henry Ford Hosp, Dept Publ Hlth Sci, Detroit, MI 48202 USA

[10] SUNY Stony Brook, Dept Prevent Med, Stony Brook, NY 11794 USA

[11] Johns Hopkins Hosp & Med Inst, James Buchanan Brady Urol Inst, Baltimore, MD 21205 USA

[12] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA

[13] Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, 1124 Columbia St, Seattle, WA 98104 USA

[14] Univ Washington, Dept Epidemiol, Sch Publ Hlth, Seattle, WA 98195 USA

[15] Vanderbilt Univ, Sch Med, Vanderbilt Epidemiol Ctr, Div Epidemiol,Dept Med, Nashville, TN 37212 USA

[16] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA

[17] SAIC Frederick Inc, NCI DCEG, Canc Genom Res Lab, Frederick, MD 21702 USA

[18] NorthShore Univ HealthSyst, Program Personalized Canc Care, Evanston, IL 60201 USA

[19] NorthShore Univ HealthSyst, Dept Surg, Evanston, IL 60201 USA

[20] Harvard Univ, Harvard Med Sch, Dept Genet, Boston, MA 02115 USA

[21] Harvard Univ, Harvard Med Sch, Howard Hughes Med Inst, Boston, MA 02115 USA

[22] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[23] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

[24] Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA

[25] Univ Calif San Diego, Sch Med, Dept Med, Howard Hughes Med Inst, San Diego, CA 92103 USA

[26] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA

[27] Korle Bu Teaching Hosp, Accra, Ghana

[28] Univ Ghana, Sch Med, Accra, Ghana

[29] Westat Corp, Rockville, MD 20850 USA

[30] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA

[31] Canc Prevent Inst Calif, Fremont, CA 94538 USA

[32] Stanford Univ, Sch Med, Palo Alto, CA 94304 USA

[33] Stanford Canc Inst, Palo Alto, CA 94304 USA

[34] Northwestern Univ, Dept Urol, Chicago, IL 60611 USA

[35] Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[36] Translat Genom Res Inst, Phoenix, AZ 85004 USA

[37] Univ West Indies, Chron Dis Res Ctr, Bridgetown, Barbados

[38] Univ West Indies, Fac Med Sci, Bridgetown, Barbados

[39] Cleveland Clin, Glickman Urol & Kidney Inst, Cleveland, OH 44106 USA

[40] Wake Forest Sch Med, Ctr Canc Genom, Winston Salem, NC 27157 USA

[41] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

[42] Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94143 USA

[43] Makerere Univ, Coll Hlth Sci, Sch Publ Hlth, Kampala, Uganda

[44] Uro Care, Kampala, Uganda

来源：

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | 2016年 / 108卷 / 07期

基金：

美国国家卫生研究院;

关键词：

GENOME-WIDE ASSOCIATION; LONG NONCODING RNA; RANGE INTERACTION; RISK; LOCI; JAPANESE; VARIANT; PCAT-1; MYC;

D O I：

10.1093/jnci/djv431

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The 8q24 region harbors multiple risk variants for distinct cancers, including > 8 for prostate cancer. In this study, we conducted fine mapping of the 8q24 risk region (127.8-128.8 Mb) in search of novel associations with common and rare variation in 4853 prostate cancer case patients and 4678 control subjects of African ancestry. All statistical tests were two-sided. We identified three independent associations at P values of less than 5.00 x 10(-8), all of which were replicated in studies from Ghana and Uganda (combined sample = 5869 case patients, 5615 control subjects; rs114798100: risk allele frequency [RAF] = 0.04, per-allele odds ratio [OR] = 2.31, 95% confidence interval [CI] = 2.04 to 2.61, P = 2.38 x 10(-40); rs72725879: RAF = 0.33, OR = 1.37, 95% CI = 1.30 to 1.45, P = 3.04 x 10(-27); and rs111906932: RAF = 0.03, OR = 1.79, 95% CI = 1.53 to 2.08, P = 1.39 x 10(-13)). Risk variants rs114798100 and rs111906923 are only found in men of African ancestry, with rs111906923 representing a novel association signal. The three variants are located within or near a number of prostate cancer-associated long noncoding RNAs (lncRNAs), including PRNCR1, PCAT1, and PCAT2. These findings highlight ancestry-specific risk variation and implicate prostate-specific lncRNAs at the 8q24 prostate cancer susceptibility region.

引用

页数：5

共 18 条

[1] 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC [J].

Ahmadiyeh, Nasim ;

Pomerantz, Mark M. ;

Grisanzio, Chiara ;

Herman, Paula ;

Jia, Li ;

Almendro, Vanessa ;

He, Housheng Hansen ;

Brown, Myles ;

Liu, X. Shirley ;

Davis, Matt ;

Caswell, Jennifer L. ;

Beckwith, Christine A. ;

Hills, Adam ;

MacConaill, Laura ;

Coetzee, Gerhard A. ;

Regan, Meredith M. ;

Freedman, Matthew L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (21) :9742-9746

[2] Multiple loci on 8q24 associated with prostate cancer susceptibility [J].

Al Olama, Ali Amin ;

Kote-Jarai, Zsofia ;

Giles, Graham G. ;

Guy, Michelle ;

Morrison, Jonathan ;

Severi, Gianluca ;

Leongamornlert, Daniel A. ;

Tymrakiewicz, Malgorzata ;

Jhavar, Sameer ;

Saunders, Ed ;

Hopper, John L. ;

Southey, Melissa C. ;

Muir, Kenneth R. ;

English, Dallas R. ;

Dearnaley, David P. ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Wilkinson, Rosemary A. ;

Sawyer, Emma ;

Lophatananon, Artitaya ;

Horwich, Alan ;

Huddart, Robert A. ;

Khoo, Vincent S. ;

Parker, Christopher C. ;

Woodhouse, Christopher J. ;

Thompson, Alan ;

Christmas, Tim ;

Ogden, Chris ;

Cooper, Colin ;

Donovan, Jenny L. ;

Hamdy, Freddie C. ;

Neal, David E. ;

Eeles, Rosalind A. ;

Easton, Douglas F. .

NATURE GENETICS, 2009, 41 (10) :1058-1060

[3] A common variant associated with prostate cancer in European and African populations [J].

Amundadottir, Laufey T. ;

Sulem, Patrick ;

Gudmundsson, Julius ;

Helgason, Agnar ;

Baker, Adam ;

Agnarsson, Bjarni A. ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Cazier, Jean-Baptiste ;

Sainz, Jesus ;

Jakobsdottir, Margret ;

Kostic, Jelena ;

Magnusdottir, Droplaug N. ;

Ghosh, Shyamali ;

Agnarsson, Kari ;

Birgisdottir, Birgitta ;

Le Roux, Louise ;

Olafsdottir, Adalheidur ;

Blondal, Thorarinn ;

Andresdottir, Margret ;

Gretarsdottir, Olafia Svandis ;

Bergthorsson, Jon T. ;

Gudbjartsson, Daniel ;

Gylfason, Arnaldur ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Kristjansson, Kristleifur ;

Geirsson, Gudmundur ;

Isaksson, Helgi ;

Douglas, Julie ;

Johansson, Jan-Erik ;

Balter, Katarina ;

Wiklund, Fredrik ;

Montie, James E. ;

Yu, Xiaoying ;

Suarez, Brian K. ;

Ober, Carole ;

Cooney, Kathleen A. ;

Gronberg, Henrik ;

Catalona, William J. ;

Einarsson, Gudmundur V. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Kong, Augustine ;

Thorsteinsdottir, Unnur ;

Stefansson, Kari .

NATURE GENETICS, 2006, 38 (06) :652-658

[4] Evaluating Genetic Risk for Prostate Cancer among Japanese and Latinos [J].

Cheng, Iona ;

Chen, Gary K. ;

Nakagawa, Hidewaki ;

He, Jing ;

Wan, Peggy ;

Laurie, Cathy C. ;

Shen, Jess ;

Sheng, Xin ;

Pooler, Loreall C. ;

Crenshaw, Andrew T. ;

Mirel, Daniel B. ;

Takahashi, Atsushi ;

Kubo, Michiaki ;

Nakamura, Yusuke ;

Al Olama, Ali Amin ;

Benlloch, Sara ;

Donovan, Jenny L. ;

Guy, Michelle ;

Hamdy, Freddie C. ;

Kote-Jarai, Zsofia ;

Neal, David E. ;

Wilkens, Lynne R. ;

Monroe, Kristine R. ;

Stram, Daniel O. ;

Muir, Kenneth ;

Eeles, Rosalind A. ;

Easton, Douglas F. ;

Kolonel, Laurence N. ;

Henderson, Brian E. ;

Le Marchand, Loic ;

Haiman, Christopher A. .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2012, 21 (11) :2048-2058

[5] Association of a novel long non-coding RNA in 8q24 with prostate cancer susceptibility [J].

Chung, Suyoun ;

Nakagawa, Hidewaki ;

Uemura, Motohide ;

Piao, Lianhua ;

Ashikawa, Kyota ;

Hosono, Naoya ;

Takata, Ryo ;

Akamatsu, Shusuke ;

Kawaguchi, Takahisa ;

Morizono, Takashi ;

Tsunoda, Tatsuhiko ;

Daigo, Yataro ;

Matsuda, Koichi ;

Kamatani, Naoyuki ;

Nakamura, Yusuke ;

Kubo, Michiaki .

CANCER SCIENCE, 2011, 102 (01) :245-252

[6] A genome-wide association study of prostate cancer in West African men [J].

Cook, Michael Blaise ;

Wang, Zhaoming ;

Yeboah, Edward D. ;

Tettey, Yao ;

Biritwum, Richard B. ;

Adjei, Andrew A. ;

Tay, Evelyn ;

Truelove, Ann ;

Niwa, Shelley ;

Chung, Charles C. ;

Chokkalingam, Annand P. ;

Chu, Lisa W. ;

Yeager, Meredith ;

Hutchinson, Amy ;

Yu, Kai ;

Rand, Kristin A. ;

Haiman, Christopher A. ;

Hoover, Robert N. ;

Hsing, Ann W. ;

Chanock, Stephen J. .

HUMAN GENETICS, 2014, 133 (05) :509-521

[7] Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men [J].

Freedman, Matthew L. ;

Haiman, Christopher A. ;

Patterson, Nick ;

McDonald, Gavin J. ;

Tandon, Arti ;

Waliszewska, Alicja ;

Penney, Kathryn ;

Steen, Robert G. ;

Ardlie, Kristin ;

John, Esther M. ;

Clakley-Girvan, Ingrid ;

Whitternore, Alice S. ;

Cooney, Kathleen A. ;

Ingles, Sue A. ;

Altshuler, David ;

Henderson, Brian E. ;

Reich, David .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (38) :14068-14073

[8] A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer [J].

Gudmundsson, Julius ;

Sulem, Patrick ;

Gudbjartsson, Daniel F. ;

Masson, Gisli ;

Agnarsson, Bjarni A. ;

Benediktsdottir, Kristrun R. ;

Sigurdsson, Asgeir ;

Magnusson, Olafur Th ;

Gudjonsson, Sigurjon A. ;

Magnusdottir, Droplaug N. ;

Johannsdottir, Hrefna ;

Helgadottir, Hafdis Th ;

Stacey, Simon N. ;

Jonasdottir, Adalbjorg ;

Olafsdottir, Stefania B. ;

Thorleifsson, Gudmar ;

Jonasson, Jon G. ;

Tryggvadottir, Laufey ;

Navarrete, Sebastian ;

Fuertes, Fernando ;

Helfand, Brian T. ;

Hu, Qiaoyan ;

Csiki, Irma E. ;

Mates, Ioan N. ;

Jinga, Viorel ;

Aben, Katja K. H. ;

van Oort, Inge M. ;

Vermeulen, Sita H. ;

Donovan, Jenny L. ;

Hamdy, Freddy C. ;

Ng, Chi-Fai ;

Chiu, Peter K. F. ;

Lau, Kin-Mang ;

Ng, Maggie C. Y. ;

Gulcher, Jeffrey R. ;

Kong, Augustine ;

Catalona, William J. ;

Mayordomo, Jose I. ;

Einarsson, Gudmundur V. ;

Barkardottir, Rosa B. ;

Jonsson, Eirikur ;

Mates, Dana ;

Neal, David E. ;

Kiemeney, Lambertus A. ;

Thorsteinsdottir, Unnur ;

Rafnar, Thorunn ;

Stefansson, Kari .

NATURE GENETICS, 2012, 44 (12) :1326-1329

[9] Multiple regions within 8q24 independently affect risk for prostate cancer [J].

Haiman, Christopher A. ;

Patterson, Nick ;

Freedman, Matthew L. ;

Myers, Simon R. ;

Pike, Malcolm C. ;

Waliszewska, Alicja ;

Neubauer, Julie ;

Tandon, Arti ;

Schirmer, Christine ;

McDonald, Gavin J. ;

Greenway, Steven C. ;

Stram, Daniel O. ;

Le Marchand, Loic ;

Kolonel, Laurence N. ;

Frasco, Melissa ;

Wong, David ;

Pooler, Loreall C. ;

Ardlie, Kristin ;

Oakley-Girvan, Ingrid ;

Whittemore, Alice S. ;

Cooney, Kathleen A. ;

John, Esther M. ;

Ingles, Sue A. ;

Altshuler, David ;

Henderson, Brian E. ;

Reich, David .

NATURE GENETICS, 2007, 39 (05) :638-644

[10] Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21 [J].

Haiman, Christopher A. ;

Chen, Gary K. ;

Blot, William J. ;

Strom, Sara S. ;

Berndt, Sonja I. ;

Kittles, Rick A. ;

Rybicki, Benjamin A. ;

Isaacs, William B. ;

Ingles, Sue A. ;

Stanford, Janet L. ;

Diver, W. Ryan ;

Witte, John S. ;

Hsing, Ann W. ;

Nemesure, Barbara ;

Rebbeck, Timothy R. ;

Cooney, Kathleen A. ;

Xu, Jianfeng ;

Kibel, Adam S. ;

Hu, Jennifer J. ;

John, Esther M. ;

Gueye, Serigne M. ;

Watya, Stephen ;

Signorello, Lisa B. ;

Hayes, Richard B. ;

Wang, Zhaoming ;

Yeboah, Edward ;

Tettey, Yao ;

Cai, Qiuyin ;

Kolb, Suzanne ;

Ostrander, Elaine A. ;

Zeigler-Johnson, Charnita ;

Yamamura, Yuko ;

Neslund-Dudas, Christine ;

Haslag-Minoff, Jennifer ;

Wu, William ;

Thomas, Venetta ;

Allen, Glenn O. ;

Murphy, Adam ;

Chang, Bao-Li ;

Zheng, S. Lilly ;

Leske, M. Cristina ;

Wu, Suh-Yuh ;

Ray, Anna M. ;

Hennis, Anselm J. M. ;

Thun, Michael J. ;

Carpten, John ;

Casey, Graham ;

Carter, Erin N. ;

Duarte, Edder R. ;

Xia, Lucy Y. .

NATURE GENETICS, 2011, 43 (06) :570-U103

← 1 2 →

共 18 条

[1] 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC [J].

Ahmadiyeh, Nasim ;

Pomerantz, Mark M. ;

Grisanzio, Chiara ;

Herman, Paula ;

Jia, Li ;

Almendro, Vanessa ;

He, Housheng Hansen ;

Brown, Myles ;

Liu, X. Shirley ;

Davis, Matt ;

Caswell, Jennifer L. ;

Beckwith, Christine A. ;

Hills, Adam ;

MacConaill, Laura ;

Coetzee, Gerhard A. ;

Regan, Meredith M. ;

Freedman, Matthew L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (21) :9742-9746

[2] Multiple loci on 8q24 associated with prostate cancer susceptibility [J].

Al Olama, Ali Amin ;

Kote-Jarai, Zsofia ;

Giles, Graham G. ;

Guy, Michelle ;

Morrison, Jonathan ;

Severi, Gianluca ;

Leongamornlert, Daniel A. ;

Tymrakiewicz, Malgorzata ;

Jhavar, Sameer ;

Saunders, Ed ;

Hopper, John L. ;

Southey, Melissa C. ;

Muir, Kenneth R. ;

English, Dallas R. ;

Dearnaley, David P. ;

Ardern-Jones, Audrey T. ;

Hall, Amanda L. ;

O'Brien, Lynne T. ;

Wilkinson, Rosemary A. ;

Sawyer, Emma ;

Lophatananon, Artitaya ;

Horwich, Alan ;

Huddart, Robert A. ;

Khoo, Vincent S. ;

Parker, Christopher C. ;

Woodhouse, Christopher J. ;

Thompson, Alan ;

Christmas, Tim ;

Ogden, Chris ;

Cooper, Colin ;

Donovan, Jenny L. ;

Hamdy, Freddie C. ;

Neal, David E. ;

Eeles, Rosalind A. ;

Easton, Douglas F. .

NATURE GENETICS, 2009, 41 (10) :1058-1060

[3] A common variant associated with prostate cancer in European and African populations [J].

Amundadottir, Laufey T. ;

Sulem, Patrick ;

Gudmundsson, Julius ;

Helgason, Agnar ;

Baker, Adam ;

Agnarsson, Bjarni A. ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Cazier, Jean-Baptiste ;

Sainz, Jesus ;

Jakobsdottir, Margret ;

Kostic, Jelena ;

Magnusdottir, Droplaug N. ;

Ghosh, Shyamali ;

Agnarsson, Kari ;

Birgisdottir, Birgitta ;

Le Roux, Louise ;

Olafsdottir, Adalheidur ;

Blondal, Thorarinn ;

Andresdottir, Margret ;

Gretarsdottir, Olafia Svandis ;

Bergthorsson, Jon T. ;

Gudbjartsson, Daniel ;

Gylfason, Arnaldur ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Kristjansson, Kristleifur ;

Geirsson, Gudmundur ;

Isaksson, Helgi ;

Douglas, Julie ;

Johansson, Jan-Erik ;

Balter, Katarina ;

Wiklund, Fredrik ;

Montie, James E. ;

Yu, Xiaoying ;

Suarez, Brian K. ;

Ober, Carole ;

Cooney, Kathleen A. ;

Gronberg, Henrik ;

Catalona, William J. ;

Einarsson, Gudmundur V. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Kong, Augustine ;

Thorsteinsdottir, Unnur ;

Stefansson, Kari .

NATURE GENETICS, 2006, 38 (06) :652-658

[4] Evaluating Genetic Risk for Prostate Cancer among Japanese and Latinos [J].

Cheng, Iona ;

Chen, Gary K. ;

Nakagawa, Hidewaki ;

He, Jing ;

Wan, Peggy ;

Laurie, Cathy C. ;

Shen, Jess ;

Sheng, Xin ;

Pooler, Loreall C. ;

Crenshaw, Andrew T. ;

Mirel, Daniel B. ;

Takahashi, Atsushi ;

Kubo, Michiaki ;

Nakamura, Yusuke ;

Al Olama, Ali Amin ;

Benlloch, Sara ;

Donovan, Jenny L. ;

Guy, Michelle ;

Hamdy, Freddie C. ;

Kote-Jarai, Zsofia ;

Neal, David E. ;

Wilkens, Lynne R. ;

Monroe, Kristine R. ;

Stram, Daniel O. ;

Muir, Kenneth ;

Eeles, Rosalind A. ;

Easton, Douglas F. ;

Kolonel, Laurence N. ;

Henderson, Brian E. ;

Le Marchand, Loic ;

Haiman, Christopher A. .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2012, 21 (11) :2048-2058

[5] Association of a novel long non-coding RNA in 8q24 with prostate cancer susceptibility [J].

Chung, Suyoun ;

Nakagawa, Hidewaki ;

Uemura, Motohide ;

Piao, Lianhua ;

Ashikawa, Kyota ;

Hosono, Naoya ;

Takata, Ryo ;

Akamatsu, Shusuke ;

Kawaguchi, Takahisa ;

Morizono, Takashi ;

Tsunoda, Tatsuhiko ;

Daigo, Yataro ;

Matsuda, Koichi ;

Kamatani, Naoyuki ;

Nakamura, Yusuke ;

Kubo, Michiaki .

CANCER SCIENCE, 2011, 102 (01) :245-252

[6] A genome-wide association study of prostate cancer in West African men [J].

Cook, Michael Blaise ;

Wang, Zhaoming ;

Yeboah, Edward D. ;

Tettey, Yao ;

Biritwum, Richard B. ;

Adjei, Andrew A. ;

Tay, Evelyn ;

Truelove, Ann ;

Niwa, Shelley ;

Chung, Charles C. ;

Chokkalingam, Annand P. ;

Chu, Lisa W. ;

Yeager, Meredith ;

Hutchinson, Amy ;

Yu, Kai ;

Rand, Kristin A. ;

Haiman, Christopher A. ;

Hoover, Robert N. ;

Hsing, Ann W. ;

Chanock, Stephen J. .

HUMAN GENETICS, 2014, 133 (05) :509-521

[7] Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men [J].

Freedman, Matthew L. ;

Haiman, Christopher A. ;

Patterson, Nick ;

McDonald, Gavin J. ;

Tandon, Arti ;

Waliszewska, Alicja ;

Penney, Kathryn ;

Steen, Robert G. ;

Ardlie, Kristin ;

John, Esther M. ;

Clakley-Girvan, Ingrid ;

Whitternore, Alice S. ;

Cooney, Kathleen A. ;

Ingles, Sue A. ;

Altshuler, David ;

Henderson, Brian E. ;

Reich, David .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (38) :14068-14073

[8] A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer [J].

Gudmundsson, Julius ;

Sulem, Patrick ;

Gudbjartsson, Daniel F. ;

Masson, Gisli ;

Agnarsson, Bjarni A. ;

Benediktsdottir, Kristrun R. ;

Sigurdsson, Asgeir ;

Magnusson, Olafur Th ;

Gudjonsson, Sigurjon A. ;

Magnusdottir, Droplaug N. ;

Johannsdottir, Hrefna ;

Helgadottir, Hafdis Th ;

Stacey, Simon N. ;

Jonasdottir, Adalbjorg ;

Olafsdottir, Stefania B. ;

Thorleifsson, Gudmar ;

Jonasson, Jon G. ;

Tryggvadottir, Laufey ;

Navarrete, Sebastian ;

Fuertes, Fernando ;

Helfand, Brian T. ;

Hu, Qiaoyan ;

Csiki, Irma E. ;

Mates, Ioan N. ;

Jinga, Viorel ;

Aben, Katja K. H. ;

van Oort, Inge M. ;

Vermeulen, Sita H. ;

Donovan, Jenny L. ;

Hamdy, Freddy C. ;

Ng, Chi-Fai ;

Chiu, Peter K. F. ;

Lau, Kin-Mang ;

Ng, Maggie C. Y. ;

Gulcher, Jeffrey R. ;

Kong, Augustine ;

Catalona, William J. ;

Mayordomo, Jose I. ;

Einarsson, Gudmundur V. ;

Barkardottir, Rosa B. ;

Jonsson, Eirikur ;

Mates, Dana ;

Neal, David E. ;

Kiemeney, Lambertus A. ;

Thorsteinsdottir, Unnur ;

Rafnar, Thorunn ;

Stefansson, Kari .

NATURE GENETICS, 2012, 44 (12) :1326-1329

[9] Multiple regions within 8q24 independently affect risk for prostate cancer [J].

Haiman, Christopher A. ;

Patterson, Nick ;

Freedman, Matthew L. ;

Myers, Simon R. ;

Pike, Malcolm C. ;

Waliszewska, Alicja ;

Neubauer, Julie ;

Tandon, Arti ;

Schirmer, Christine ;

McDonald, Gavin J. ;

Greenway, Steven C. ;

Stram, Daniel O. ;

Le Marchand, Loic ;

Kolonel, Laurence N. ;

Frasco, Melissa ;

Wong, David ;

Pooler, Loreall C. ;

Ardlie, Kristin ;

Oakley-Girvan, Ingrid ;

Whittemore, Alice S. ;

Cooney, Kathleen A. ;

John, Esther M. ;

Ingles, Sue A. ;

Altshuler, David ;

Henderson, Brian E. ;

Reich, David .

NATURE GENETICS, 2007, 39 (05) :638-644

[10] Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21 [J].

Haiman, Christopher A. ;

Chen, Gary K. ;

Blot, William J. ;

Strom, Sara S. ;

Berndt, Sonja I. ;

Kittles, Rick A. ;

Rybicki, Benjamin A. ;

Isaacs, William B. ;

Ingles, Sue A. ;

Stanford, Janet L. ;

Diver, W. Ryan ;

Witte, John S. ;

Hsing, Ann W. ;

Nemesure, Barbara ;

Rebbeck, Timothy R. ;

Cooney, Kathleen A. ;

Xu, Jianfeng ;

Kibel, Adam S. ;

Hu, Jennifer J. ;

John, Esther M. ;

Gueye, Serigne M. ;

Watya, Stephen ;

Signorello, Lisa B. ;

Hayes, Richard B. ;

Wang, Zhaoming ;

Yeboah, Edward ;

Tettey, Yao ;

Cai, Qiuyin ;

Kolb, Suzanne ;

Ostrander, Elaine A. ;

Zeigler-Johnson, Charnita ;

Yamamura, Yuko ;

Neslund-Dudas, Christine ;

Haslag-Minoff, Jennifer ;

Wu, William ;

Thomas, Venetta ;

Allen, Glenn O. ;

Murphy, Adam ;

Chang, Bao-Li ;

Zheng, S. Lilly ;

Leske, M. Cristina ;

Wu, Suh-Yuh ;

Ray, Anna M. ;

Hennis, Anselm J. M. ;

Thun, Michael J. ;

Carpten, John ;

Casey, Graham ;

Carter, Erin N. ;

Duarte, Edder R. ;

Xia, Lucy Y. .

NATURE GENETICS, 2011, 43 (06) :570-U103

← 1 2 →