Redistribution, homing and organ-invasion of neoplastic stem cells in myeloid neoplasms

被引：13

作者：

Valent, Peter ^{[1
,2
]}

Sadovnik, Irina ^{[1
,2
]}

Eisenwort, Gregor ^{[1
,2
]}

Herrmann, Harald ^{[2
,3
]}

Bauer, Karin ^{[1
,2
]}

Mueller, Niklas ^{[1
,4
]}

Sperr, Wolfgang R. ^{[1
,2
]}

Wicklein, Daniel ^{[5
]}

Schumacher, Udo ^{[5
]}

机构：

[1] Med Univ Vienna, Dept Internal Med 1, Div Hematol & Hemostaseol, Vienna, Austria

[2] Med Univ Vienna, Ludwig Boltzmann Inst Hematol & Oncol, Vienna, Austria

[3] Med Univ Vienna, Dept Radiotherapy, Dept Med 3, Vienna, Austria

[4] Hosp Ludwig Maximilians Univ Munich, Dept Internal Med 3, Div Hematol & Oncol, Munich, Germany

[5] Univ Med Ctr Hamburg Eppendorf, Univ Canc Ctr, Inst Anat & Expt Morphol, Hamburg, Germany

来源：

SEMINARS IN CANCER BIOLOGY | 2020年 / 60卷

基金：

奥地利科学基金会;

关键词：

Neoplastic stem cells; Stem cell niche; Extramedullary myelopoiesis; Leukemia; Stem cell invasion; Myeloid sarcoma; Mast cell sarcoma; BONE-MARROW NICHE; EXTRAMEDULLARY BLAST CRISIS; ENDOTHELIAL GROWTH-FACTOR; MINIMAL RESIDUAL DISEASE; L-SELECTIN EXPRESSION; LEUKEMIA STEM; HEMATOPOIETIC STEM; ADHESION MOLECULES; PROGENITOR CELLS; MAST-CELL;

D O I：

10.1016/j.semcancer.2019.07.025

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The development of a myeloid neoplasm is a step-wise process that originates from leukemic stem cells (LSC) and includes pre-leukemic stages, overt leukemia and a drug-resistant terminal phase. Organ-invasion may occur in any stage, but is usually associated with advanced disease and a poor prognosis. Sometimes, extra-medullary organ invasion shows a metastasis-like or even sarcoma-like destructive growth of neoplastic cells in local tissue sites. Examples are myeloid sarcoma, mast cell sarcoma and localized blast phase of chronic myeloid leukemia. So far, little is known about mechanisms underlying re-distribution and extramedullary dissemination of LSC in myeloid neoplasms. In this article, we discuss mechanisms through which LSC can mobilize out of the bone marrow niche, can transmigrate from the blood stream into extramedullary organs, can invade local tissue sites and can potentially create or support the formation of local stem cell niches. In addition, we discuss strategies to interfere with LSC expansion and organ invasion by targeted drug therapies.

引用

页码：191 / 201

页数：11

共 169 条

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