Effect of 2,5-dimethylpyrazine on uterine contraction in late stage of pregnant female rats

被引：6

作者：

Yamada, K ^{[1
]}

Sano, N ^{[1
]}

Fujihara, H ^{[1
]}

Ohta, A ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Hachioji, Tokyo 1920392, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2003年 / 26卷 / 11期

关键词：

2,5-dimethylpyrazine; pregnant uterine contraction; inhibition; oxytocic agent;

D O I：

10.1248/bpb.26.1614

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Effect of 2,5-dimethylpyrazine (2,5-DMP) on oxytocic agent-induced late pregnant uterine contraction in female rats was studied. Oxytocic agents induced-hypercontraction in the late phase of pregnant uterine movements were inhibited by administration of 2,5-DMP. The inhibition of uterine contraction was obtained more strengthening by presence of a low dose of ritodrine hydrochloride than 2,5-DMP alone. These results suggests that 2,5-DMP has an inhibitory action on uterine hypercontraction induced by oxytocic agent through the beta(2)-adrenoceptor in the pregnant uterus and supports the appllicability of relaxing drugs for oxytocic agent-induced accidents.

引用

页码：1614 / 1617

页数：4

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