Effect of 2,5-dimethylpyrazine on uterine contraction in late stage of pregnant female rats

被引：6
|
作者：
Yamada, K [1 ]
Sano, N [1 ]
Fujihara, H [1 ]
Ohta, A [1 ]
机构：
[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Hachioji, Tokyo 1920392, Japan
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2003年 / 26卷 / 11期
关键词：
2,5-dimethylpyrazine; pregnant uterine contraction; inhibition; oxytocic agent;
D O I：
10.1248/bpb.26.1614
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Effect of 2,5-dimethylpyrazine (2,5-DMP) on oxytocic agent-induced late pregnant uterine contraction in female rats was studied. Oxytocic agents induced-hypercontraction in the late phase of pregnant uterine movements were inhibited by administration of 2,5-DMP. The inhibition of uterine contraction was obtained more strengthening by presence of a low dose of ritodrine hydrochloride than 2,5-DMP alone. These results suggests that 2,5-DMP has an inhibitory action on uterine hypercontraction induced by oxytocic agent through the beta(2)-adrenoceptor in the pregnant uterus and supports the appllicability of relaxing drugs for oxytocic agent-induced accidents.
引用
收藏
页码：1614 / 1617
页数：4
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