Preparation and evaluation of porous poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)-hydroxyapatite composite scaffolds

被引：28

作者：

Xi, Jing ^{[1
]}

Zhang, Ling ^{[1
]}

Zheng, Zhenhuan ^{[1
]}

Chen, Guoqiang ^{[1
]}

Gong, Yandao ^{[1
]}

Zhao, Nanming ^{[1
]}

Zhang, Xiufang ^{[1
]}

机构：

[1] Tsing Hua Univ, State Key Lab Biomembrane & Membrane Biotechnol, Dept Biol Sci & Biotechnol, Beijing 100084, Peoples R China

来源：

JOURNAL OF BIOMATERIALS APPLICATIONS | 2008年 / 22卷 / 04期

关键词：

PHBHHx; hydroxyapatite; porous scaffold; bone reconstruction;

D O I：

10.1177/0885328207075425

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) and PHBHHx-hydroxyapatite (HAP) composite scaffolds have been prepared by phase separation and subsequent sublimation of the solvent for bone tissue engineering. Scanning electron microscopy (SEM), porosity measurement, mechanical tests, and thermogravimertric analysis (TGA) are used to analyze the physical properties of the scaffolds. The biocompatibility and osteoconductivity are assessed by examining the morphology, proliferation, and differentiation of MC3T3-E1 osteoprogenitor cells seeded on the scaffolds. The PHBHHx-HAP composite scaffolds show better mechanical properties, biocompatibility, and osteoconductivity than the PHBHHx scaffolds. The results suggest that PHBHHx-HAP composite scaffolds can be employed as a promising candidate for bone reconstruction.

引用

页码：293 / 307

页数：15

共 32 条

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