Neurostimulation Combined With Cognitive Intervention in Alzheimer's Disease (NeuroAD): Study Protocol of Double-Blind, Randomized, Factorial Clinical Trial

被引：10

作者：

Andrade, Suellen Marinho ^{[1
]}

de Oliveira, Eliane Araujo ^{[1
]}

Alves, Nelson Torro ^{[1
,2
]}

Gomes dos Santos, Ana Cristina ^{[1
,3
]}

Ponce Leon de Mendonca, Camila Teresa ^{[1
,2
]}

Amorim Sampaio, Danielle Dorand ^{[1
]}

Querino Cavalcante da Silva, Edyllaine Elidy ^{[1
]}

Goncalves da Fonseca, Egina Karoline ^{[1
,2
]}

de Almeida Rodrigues, Evelyn Thais ^{[1
,2
]}

Siqueira de Lima, Gabriela Nayara ^{[1
,3
]}

Carvalho, Jamerson ^{[1
,2
]}

Silvestre da Silva, Jessyca Alves ^{[1
,3
]}

Toledo, Manuella ^{[1
,4
]}

Diniz da Rosa, Marine Raquel ^{[1
,5
]}

de Carvalho Gomes, Marcia Queiroz ^{[1
,3
]}

de Oliveira, Melquisedek Monteiro ^{[1
]}

Maia Lemos, Moema Teixeira ^{[1
]}

Lima, Nagylla Gomes ^{[1
]}

Inacio, Penha ^{[1
,3
]}

da Cruz Ribeiro e Rodrigues, Petra Maria ^{[1
]}

Dantas Ferreira, Rayssa Gabriela ^{[1
,3
]}

Cavalcante, Renata ^{[1
,3
]}

Lyra de Brito Aranha, Renata Emanuela ^{[1
]}

Neves, Regina ^{[1
,6
]}

da Costa e Souza, Rodrigo Marmo ^{[1
,2
]}

Portugal, Thaina Magalhaes ^{[1
]}

Nascimento Martins, Wanessa Kallyne ^{[1
]}

Pontes, Vivian ^{[1
]}

de Paiva Fernandes, Thiago Monteiro ^{[1
,2
]}

Contador, Israel ^{[2
,7
]}

Fernandez-Calvo, Bernardino ^{[1
,2
]}

机构：

[1] Univ Fed Paraiba, Dept Physiotherapy, Joao Pessoa, Paraiba, Brazil

[2] Univ Fed Paraiba, Dept Psychol, Joao Pessoa, Paraiba, Brazil

[3] Univ Fed Paraiba, Dept Occupat Therapy, Joao Pessoa, Paraiba, Brazil

[4] Univ Fed Paraiba, Dept Internal Med, Joao Pessoa, Paraiba, Brazil

[5] Univ Fed Paraiba, Dept Speech Language Pathol & Audiol, Joao Pessoa, Paraiba, Brazil

[6] Brazilian Alzheimers Assoc, Joao Pessoa, Paraiba, Brazil

[7] Univ Salamanca, Dept Basic Psychol Psychobiol & Methodol Behav Sc, Salamanca, Spain

来源：

FRONTIERS IN AGING NEUROSCIENCE | 2018年 / 10卷

关键词：

clinical trial; dementia; neuropsychology; non-pharmacological approaches; transcranial direct current stimulation; neuromodulation; DIRECT-CURRENT STIMULATION; NONINVASIVE BRAIN-STIMULATION; TRANSCRANIAL MAGNETIC STIMULATION; WORKING-MEMORY; PREFRONTAL CORTEX; ADULT AGE; TDCS; DEMENTIA; REHABILITATION; EFFICACY;

D O I：

10.3389/fnagi.2018.00334

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Despite advances in the treatment of Alzheimer's disease (AD), there is currently no prospect of a cure, and evidence shows that multifactorial interventions can benefit patients. A promising therapeutic alternative is the use of transcranial direct current stimulation (tDCS) simultaneously with cognitive intervention. The combination of these non-pharmacological techniques is apparently a safe and accessible approach. This study protocol aims to compare the efficacy of tDCS and cognitive intervention in a double-blind, randomized and factorial clinical trial. One hundred participants diagnosed with mild-stage AD will be randomized to receive both tDCS and cognitive intervention, tDCS, cognitive intervention, or placebo. The treatment will last 8 weeks, with a 12-month follow-up. The primary outcome will be the improvement of global cognitive functions, evaluated by the AD Assessment Scale, cognitive subscale (ADAS-Cog). The secondary outcomes will include measures of functional, affective, and behavioral components, as well as a neurophysiological marker (Brain-derived neurotrophic factor, BDNF). This study will enable us to assess, both in the short and long term, whether tDCS is more effective than the placebo and to examine the effects of combined therapy (tDCS and cognitive intervention) and isolated treatments (tDCS vs. cognitive intervention) on patients with AD.

引用

页数：14

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