A Review of the Role of Hypoxia in Radioresistance in Cancer Therapy

被引:67
作者
Bouleftour, Wafa [1 ]
Rowinski, Elise [1 ]
Louati, Safa [2 ,3 ,4 ]
Sotton, Sandrine [1 ]
Wozny, Anne-Sophie [2 ,3 ,4 ]
Moreno-Acosta, Pablo [5 ]
Mery, Benoite [1 ]
Rodriguez-Lafrasse, Claire [2 ,3 ,4 ]
Magne, Nicolas [1 ,2 ,3 ,4 ]
机构
[1] Lucien Neuwirth Cancerol Inst, Radiotherapy Dept, St Priest En Jarez, France
[2] Univ Lyon 1, Fac Med Lyon Sud, Oullins, France
[3] IPNL, Lab Radiobiol Cellulaire & Mol, Inst Phys Nucl Lyon, CNRS,UMR 5822, Villeurbanne, France
[4] Hosp Civils Lyon, Lyon, France
[5] Natl Canc Inst, Res Grp Canc Biol, Bogota, Colombia
来源
MEDICAL SCIENCE MONITOR | 2021年 / 27卷
关键词
Cancer; Familial; with In Vitro Radioresistance; Hypoxia-Inducible Factor 1; Radiotherapy; NECK-CANCER; TUMOR HYPOXIA; ACCELERATED RADIOTHERAPY; INDUCIBLE FACTOR-1-ALPHA; PROSTATE-CANCER; DOWN-REGULATION; STEM-CELLS; HEAD; RADIATION; MECHANISMS;
D O I
10.12659/MSM.934116
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Hypoxia involves neoplastic cells. Unlike normal tissue, solid tumors are composed of aberrant vasculature, leading to a hypoxic microenvironment. Hypoxia is also known to be involved in both metastasis initiation and therapy resistance. Radiotherapy is the appropriate treatment in about half of all cancers, but loco-regional control failure and a disease recurrence often occur due to clinical radioresistance. Hypoxia induces radioresistance through a number of molecular pathways, and numerous strategies have been developed to overcome this. Nevertheless, these strategies have resulted in disappointing results, including adverse effects and limited efficacy. Additional clinical studies are needed to achieve a better understanding of the complex hypoxia pathways. This review presents an update on the mechanisms of hypoxia in radioresistance in solid tumors and the potential therapeutic solutions.
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页数:7
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