Allele-specific expression of the PSP gene in the mouse sublingual glands

被引：1
|
作者：
Laursen, J [1 ]
Larsen, HJ [1 ]
Mikkelsen, TR [1 ]
Hjorth, JP [1 ]
机构：
[1] Aarhus Univ, Dept Mol & Struct Biol, DK-8000 Aarhus, Denmark
来源：
GENETICAL RESEARCH | 1998年 / 71卷 / 03期
关键词：
D O I：
10.1017/S0016672398003280
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
There are two known alleles of the mouse parotid secretory protein (PSP) gene: Psp(a) and Psp(b). Psp(a) is carried by DBA/2J mice and Psp(b) is carried by C57BL/6J mice. Eighty-eight mice derived from a F-1(C57BL/6J x DBA/2J) to DBA/2J backcross were analysed for PSP mRNA expression in the sublingual glands. Expression was found in heterozygous mice only. This indicates that only Psp(b) is expressed in this tissue. Furthermore, it maps the allele-specific sublingual gland determinant within 3.4 cM of Psp. Previous analysis of Psp(b) identified an enhancer-like region in position -4.6 to -3.1 kb that was necessary for transgene expression in the sublingual glands. Here it is shown that the corresponding region in Psp(a) enhances transgene expression in the sublingual glands as efficiently. The implications for regulation of PSP mRNA expression in the sublingual glands are discussed.
引用
收藏
页码：187 / 191
页数：5
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