Maternal exposure to ambient air pollution and fetal growth in North-East Scotland: A population-based study using routine ultrasound scans

被引:68
作者
Clemens, Tom [1 ]
Turner, Steve [2 ]
Dibben, Chris [1 ]
机构
[1] Univ Edinburgh, Sch Geosci, Edinburgh, Midlothian, Scotland
[2] Univ Aberdeen, Child Hlth, Aberdeen, Scotland
基金
英国医学研究理事会;
关键词
Fetal growth; Ambient air pollution; Maternal health; In utero; Scotland; FINE PARTICULATE MATTER; FRACTIONAL POLYNOMIALS; CIGARETTE-SMOKING; PRENATAL EXPOSURE; LUNG-CANCER; ASSOCIATIONS; PREGNANCY; BIRTH; RISK; MORTALITY;
D O I
10.1016/j.envint.2017.07.018
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Background: Maternal ambient air pollution exposure is associated with reduced birthweight. Few studies have examined the effect on growth in utero and none have examined the effect of exposure to particulates less than 2.5 mu m (PM2.5) and possible effect modification by smoking status. Objectives: Examine the effect of maternal exposure to ambient concentrations of PM10, PM2.5 and nitrogen dioxide (NO2) for in utero fetal growth, size at birth and effect modification by smoking status. Methods: Administratively acquired second and third trimester fetal measurements (bi-parietal diameter, femur length and abdominal circumference), birth outcomes (weight, crown heel length and occipito-frontal circumference) and maternal details were obtained from routine fetal ultrasound scans and maternity records (period 1994-2009). These were modelled against residential annual pollution concentrations (calendar year mean) adjusting for covariates and stratifying by smoking status. Results: In the whole sample (n= 13,775 pregnancies), exposure to PM10, PM2.5 and NO2 was associated with reductions in measurements at birth and biparietal diameter from late second trimester onwards. Among mothers who did not smoke at all during pregnancy (n= 11,075), associations between biparietal diameter and pollution exposure remained significant but were insignificant among those who did smoke (n= 2700). Femur length and abdominal circumference were not significantly associated with pollution exposure. Conclusions: Fetal growth is strongly associated with particulates exposure from later in second trimester onwards but the effect appears to be subsumed by smoking. Typical ambient exposures in this study were relatively low compared to other studies and given these results, it may be necessary to consider reducing recommended "safe" ambient air exposures.
引用
收藏
页码:216 / 226
页数:11
相关论文
共 37 条
[1]   Prenatal Exposure to Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth in the INMA Sabadell Cohort [J].
Aguilera, Inmaculada ;
Garcia-Esteban, Raquel ;
Iniguez, Carmen ;
Nieuwenhuijsen, Mark J. ;
Rodriguez, Agueda ;
Paez, Montserrat ;
Ballester, Ferran ;
Sunyer, Jordi .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2010, 118 (05) :705-711
[2]  
[Anonymous], ENV HLTH PERSPECT
[3]  
[Anonymous], 2016, Working Party Report of the Royal College of Physicians.
[4]   Data Resource Profile: The Aberdeen Maternity and Neonatal Databank (AMND) [J].
Ayorinde, Abimbola A. ;
Wilde, Katie ;
Lemon, John ;
Campbell, Doris ;
Bhattacharya, Sohinee .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2016, 45 (02) :389-394
[5]   Measurement error in time-series analysis: a simulation study comparing modelled and monitored data [J].
Butland, Barbara K. ;
Armstrong, Ben ;
Atkinson, Richard W. ;
Wilkinson, Paul ;
Heal, Mathew R. ;
Doherty, Ruth M. ;
Vieno, Massimo .
BMC MEDICAL RESEARCH METHODOLOGY, 2013, 13
[6]   Associations of maternal personal exposure to air pollution on fetal weight and fetoplacental Doppler: A prospective cohort study [J].
Carvalho, Mariana A. ;
Bernardes, Lisandra S. ;
Hettfleisch, Karen ;
Pastro, Luciana D. M. ;
Vieira, Sandra E. ;
Saldiva, Silvia R. D. M. ;
Saldiva, Paulo H. N. ;
Francisco, Rossana P. V. .
REPRODUCTIVE TOXICOLOGY, 2016, 62 :9-17
[7]   Reference values for fetal limb biometry at 10-14 weeks of gestation [J].
De Biasio, P ;
Prefumo, F ;
Lantieri, PB ;
Venturini, PL .
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2002, 19 (06) :588-591
[8]  
DEFRA, 2015, 2010 2015 GOV POL EN
[10]   Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells [J].
Geiser, M ;
Rothen-Rutishauser, B ;
Kapp, N ;
Schürch, S ;
Kreyling, W ;
Schulz, H ;
Semmler, M ;
Hof, VI ;
Heyder, J ;
Gehr, P .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2005, 113 (11) :1555-1560