An Overview of the Mechanisms of Marine Fungi-Derived Anti-Inflammatory and Anti-Tumor Agents and their Novel Role in Drug Targeting

被引:29
作者
Hassan, Syed Shams ul [1 ]
Ishaq, Muhammad [1 ]
Zhang, Wei-dong [1 ,2 ]
Jin, Hui-Zi [1 ,2 ]
机构
[1] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai Key Lab Mol Engn Chiral Drugs, Shanghai 200240, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Pharm, Dept Nat Prod Chem, Shanghai 200240, Peoples R China
关键词
Marine fungi; anti-inflammatory; anticancer; mode of action; chemical structures; diagrammed illustrations; medicines; NF-KAPPA-B; LIPOPOLYSACCHARIDE-STIMULATED RAW264.7; MAPK PATHWAYS; TLR4-MYD88-MEDIATED INHIBITION; CELL-DEATH; APOPTOSIS; AUTOPHAGY; ANGIOGENESIS; METABOLITES; VEGF;
D O I
10.2174/1381612826666200728142244
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Marine fungi with their successful pharmacological effects were considered to be the treasure of ocean medicines concerning the striking ability of their secondary metabolites. Literature over literature has been published on fungi derived bioactive molecules to probe its therapeutic potential. Marine fungi have an implicit to cede future medicines against life-threatening diseases, such as cancer and several emerging inflammations. The biological actions of many marine fungi-derived secondary metabolites are still unlocked, for an assorted number of bioactive compounds by which they interact with human diseases are discussed here with comprehensive diagrams. This knowledge is one of the main tracks to be established specifically for the successful transformation of bioactive compounds to medicines. Marine fungi produce a diverse range of biochemical substances with precious carbon scaffolds, which are the main component interplaying with human diseases at distinctive spots. Specific diseases having a flair to fight at distinctive targets within the body can lead to a new trend of raising the chances of developing targeted drugs.
引用
收藏
页码:2605 / 2614
页数:10
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