Epigenetic Regulation of Breast Cancer Stem Cells Contributing to Carcinogenesis and Therapeutic Implications

被引：16

作者：

Wu, Hsing-Ju ^{[1
,2
,3
]}

Chu, Pei-Yi ^{[4
,5
,6
,7
]}

机构：

[1] Natl Changhua Univ Educ, Dept Biol, Changhua 500, Taiwan

[2] Show Chwan Mem Hosp, Res Assistant Ctr, Changhua 500, Taiwan

[3] Chang Bing Show Chwan Mem Hosp, Dept Med Res, Changhua 505, Taiwan

[4] Fu Jen Catholic Univ, Coll Med, Sch Med, New Taipei 242, Taiwan

[5] Show Chwan Mem Hosp, Dept Pathol, Changhua 500, Taiwan

[6] Chung Chou Univ Sci & Technol, Dept Hlth Food, Changhua 510, Taiwan

[7] Natl Inst Canc Res, Natl Hlth Res Inst, Tainan 704, Taiwan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 15期

关键词：

breast cancer; breast cancer stem cells; epigenetic regulation; therapies; EPITHELIAL-MESENCHYMAL TRANSITION; HISTONE DEACETYLASE INHIBITORS; LONG NONCODING RNAS; DEMETHYLASE; LSD1; DNA METHYLATION; TUMOR-GROWTH; SELF-RENEWAL; PARP INHIBITORS; DOWN-REGULATION; LINCRNA HOTAIR;

D O I：

10.3390/ijms22158113

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Globally, breast cancer has remained the most commonly diagnosed cancer and the leading cause of cancer death among women. Breast cancer is a highly heterogeneous and phenotypically diverse group of diseases, which require different selection of treatments. Breast cancer stem cells (BCSCs), a small subset of cancer cells with stem cell-like properties, play essential roles in breast cancer progression, recurrence, metastasis, chemoresistance and treatments. Epigenetics is defined as inheritable changes in gene expression without alteration in DNA sequence. Epigenetic regulation includes DNA methylation and demethylation, as well as histone modifications. Aberrant epigenetic regulation results in carcinogenesis. In this review, the mechanism of epigenetic regulation involved in carcinogenesis, therapeutic resistance and metastasis of BCSCs will be discussed, and finally, the therapies targeting these biomarkers will be presented.

引用

页数：30

共 247 条

[1]

Abdel-Hafiz Hany A, 2017, Diseases, V5, DOI 10.3390/diseases5030016

[2] Prospective identification of tumorigenic breast cancer cells [J].