Effect of rutin on proinflammatory cytokines and oxidative stress in toxin-mediated hepatotoxicity

被引：5

作者：

AlDrak, Noura ^{[1
]}

Abudawood, Manal ^{[1
]}

Hamed, Sherifa S. ^{[2
,3
]}

Ansar, Sabah ^{[1
]}

机构：

[1] King Saud Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Riyadh, Saudi Arabia

[2] King Saud Univ, Coll Sci, Zool Dept, Riyadh, Saudi Arabia

[3] Univ Alexandria, Fac Sci, Zool Dept, Alexandria, Egypt

来源：

TOXIN REVIEWS | 2018年 / 37卷 / 03期

关键词：

Lead; rutin; antioxidant enzymes; hepatotoxicity; NITRILOTRIACETATE-INDUCED HEPATOTOXICITY; LEAD TOXICITY; ANTIOXIDANT DEFENSE; DIALLYL TRISULFIDE; TARTARY BUCKWHEAT; TRACE-ELEMENTS; ASCORBIC-ACID; ION PROFILE; QUERCETIN; FLAVONOIDS;

D O I：

10.1080/15569543.2017.1354305

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The present study was designed to evaluate the effect of rutin (RT) on lead (Pb)-induced oxidative stress. Rats were divided into groups and were treated with RT with or without lead. Levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), tumor necrosis factor- (TNF-), interleukin-6 (IL-6), and interleukin-1 (IL-1) were evaluated. Levels of AST, ALT, TNF-, IL-6, and IL-1 were significantly decreased, and the activities of antioxidant enzymes were increased in the liver of rats treated with RT along with Pb. Histologic changes were improved to almost a normal hepatic structure. The results suggest that RT controls the damaged antioxidant status in Pb-induced oxidative stress.

引用

页码：223 / 230

页数：8

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