Different patterns of activation markers expression and CD4+T-cell responses to ex vivo stimulation in patients with clinically quiescent multiple sclerosis (MS)

被引：16

作者：

Kosmaczewska, A.

Bilinska, M.

Ciszak, L.

Noga, L.

Pawlak, E.

Szteblich, A.

Podemski, R.

Frydecka, I.

机构：

[1] Polish Acad Sci, Inst Immunol & Expt Therapy, Dept Expt Therapy, Immunopathol Lab, PL-53114 Wroclaw, Poland

[2] Wroclaw Med Univ, Dept Neurol, PL-50420 Wroclaw, Poland

[3] Wroclaw Med Univ, Dept Hematol, PL-50420 Wroclaw, Poland

[4] Wroclaw Med Univ, Dept Pathophysiol, PL-50420 Wroclaw, Poland

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2007年 / 189卷 / 1-2期

关键词：

multiple sclerosis; remission; CTLA-4; IFN-gamma; activated CD4+T cells; sCTLA-4;

D O I：

10.1016/j.jneuroim.2007.06.021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Patients with relapsing-remitting (RR) and secondary progressive (SP) forms of multiple sclerosis (MS), although in long-term clinical remission, showed different patterns of increased expressions of the activation markers: CD69, CD40L, and both membrane/surface and cytoplasmic CTLA-4 (mCTLA-4 and cCTLA-4, respectively) in freshly isolated peripheral blood (PB) CD4+ T cells compared with controls. Also observed were dysregulated responses to ex vivo stimulation in both groups of MS patients accompanied by increased IFN-gamma synthesis. Our findings may suggest that the mechanisms leading to each clinical form of the disease may be heterogeneous. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：137 / 146

页数：10

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