Severe anemia affects both splenectomized and non-splenectomized Plasmodium faiciparum-infected Aotus infulatus monkeys

被引:0
作者
Carvalho, LJD
Alves, FA
Oliveira, SGD
Valle, RD
Fernandes, AAM
Muniz, JAPC
Daniel-Ribeiro, CT
机构
[1] Fiocruz MS, Inst Oswaldo Cruz, WHO Collaborating Ctr Res & Training Immunol Para, Dept Imunol,Lab Pesquisas Malaria, BR-21045900 Rio De Janeiro, Brazil
[2] Ctr Nacl Primatas, Belem, Para, Brazil
[3] Inst Evandro Chagas, Belem, Para, Brazil
来源
MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2003年 / 98卷 / 05期
关键词
malaria; Plasmodium falciparum; Aotus infulatus; primate model;
D O I
暂无
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Severe anemia is the earliest and a frequently fatal complication of Plasmodium falciparum infection. Here we describe Aotus infulatus as a primate model suitable to study this malaria complication. Both non-splenectomized and splenectomized monkeys receiving different inocula of P. falciparum FVO strain presented large (> 50%) decreases in hematocrit values during infection. Non-splenectomized animals were able to control parasite growth (parasitemia did not exceed 4%), but they had to be treated because of severe anemia. Three of 4 splenectomized monkeys did not control parasitemia and were treated, but developed severe anemia after treatment when presenting a negative blood film. Destruction of parasitized red blood cells alone cannot account for the degree of anemia. Non-splenectomized monkeys repeatedly infected with homologous parasites became rapidly and progressively resistant to reinfection and to the development of severe anemia. The data presented here point to A. infulatus as a suitable model for studying the pathogenesis of severe malarial infection.
引用
收藏
页码:679 / 686
页数:8
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