Lead Poisoning: Basics and New Developments

• Based on strong research evidence, no measurable BLL is considered safe. • Because neurotoxicity associated with lower BLLs has been established by overwhelmingly consistent evidence from meta-analysis of several cohort studies, primary prevention of lead exposure is of paramount importance. • Lead exerts its effects on multiple body systems (some evidence), with the developing brain being particularly vulnerable (strong evidence). • No current evidence shows that pharmacotherapy in patients who have high BLLs reverses lead neurotoxicity. Targeted at-risk screening and early intervention for elevated BLLs, as currently recommended by the CDC and the American Academy of Pediatrics, should be conducted by every primary care practitioner to minimize the deleterious effects of lead in children.