LC Separation of γ-Amino Acid Enantiomers

被引：7

作者：

Pataj, Zoltan ^{[1
]}

Ilisz, Istvan ^{[1
]}

Aranyi, Anita ^{[1
]}

Forro, Eniko ^{[2
]}

Fulop, Ferenc ^{[2
]}

Armstrong, Daniel W. ^{[3
]}

Peter, Antal ^{[1
]}

机构：

[1] Univ Szeged, Dept Inorgan & Analyt Chem, H-6720 Szeged, Hungary

[2] Univ Szeged, Inst Pharmaceut Chem, H-6720 Szeged, Hungary

[3] Univ Texas Arlington, Dept Chem & Biochem, Arlington, TX 76019 USA

来源：

CHROMATOGRAPHIA | 2010年 / 71卷

基金：

匈牙利科学研究基金会; 美国国家卫生研究院;

关键词：

Column liquid chromatography; Enantiomer separation; gamma-Amino acid analogs; Macrocyclic glycopeptide-based columns; CHIRAL STATIONARY-PHASE; DRUG-RESISTANT EPILEPSY; CHIROBIOTIC-T; TAG COLUMNS; PERFORMANCE; VIGABATRIN; GABA;

D O I：

10.1365/s10337-010-1484-2

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Three underivatized gamma-amino acids were successfully enantioseparated by high-performance liquid chromatography on macrocyclic glycopeptide based chiral stationary phases. The effects of the alcohol modifier in the mobile phase and the column temperature on the enantioseparation were investigated. Apparent thermodynamic parameters were calculated from the plots of ln k or ln alpha versus 1/T. Some mechanistic aspects of chiral recognition are discussed with respect to the structures of the analytes. It was found that the enantioseparations were enthalpy-driven, the double bond in the analyte exerting a significant influence on the chiral recognition.

引用

页码：S13 / S19

页数：7

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