Damipipecolin and damituricin, novel bioactive bromopyrrole alkaloids from the Mediterranean sponge Axinella damicornis

被引：34
作者：
Aiello, Anna
Fattorusso, Ernesto
Giordano, Antonella
Menna, Marialuisa
Mueller, Werner E. G.
Perovic-Ottstadt, Sanja
Schroeder, Heinz C.
机构：
[1] Univ Naples Federico 2, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy
[2] Univ Mainz, Inst Physiol Chem, Abt Angew Mol Biol, D-55099 Mainz, Germany
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2007年 / 15卷 / 17期
关键词：
marine sponges; natural products; bromopyrrole alkaloids; axinella domicornis; scrotonin receptor activity;
D O I：
10.1016/j.bmc.2007.05.074
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new bromopyrrole alkaloids, damipipecolin (1) and damituricin (2), have been isolated from the Mediterranean sponge Axinella danticornis, and their structures established through spectroscopic methods. Compounds 1 and 2 extend the structural variety of the so far known pyrrole alkaloids; in these compounds, the 4-bromopyrrole 2-carboxylic acid is directly condensed with a non-protein cyclic alpha-amino acid, the (2R, 4R)-trans-4-hydroxypipecolic acid and (2R, 4R)-cis-N,N'-dimethyl-4-hydroxyproline (D-turicine) in I and 2, respectively. Compounds I and 2 were found to display a modulating effect of the serotonin receptor activity in vitro. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5877 / 5887
页数：11
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