C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

被引：867

作者：

Hoeffel, Guillaume ^{[1
]}

Chen, Jinmiao ^{[1
]}

Lavin, Yonit ^{[2
,3
]}

Low, Donovan ^{[1
]}

Almeida, Francisca F. ^{[1
]}

See, Peter ^{[1
]}

Beaudin, Anna E. ^{[4
]}

Lum, Josephine ^{[1
]}

Low, Ivy ^{[1
]}

Forsberg, E. Camilla ^{[4
]}

Poidinger, Michael ^{[1
]}

Zolezzi, Francesca ^{[1
]}

Larbi, Anis ^{[1
]}

Ng, Lai Guan ^{[1
]}

Chan, Jerry K. Y. ^{[1
,5
,6
,7
]}

Greter, Melanie ^{[8
]}

Becher, Burkhard ^{[8
]}

Samokhvalov, Igor M. ^{[9
]}

Merad, Miriam ^{[2
,3
]}

Ginhoux, Florent ^{[1
]}

机构：

[1] ASTAR, Singapore Immunol Network SIgN, BIOPOLIS, Singapore 138648, Singapore

[2] Tisch Canc Inst, Dept Oncol Sci, New York, NY 10029 USA

[3] Icahn Sch Med Mt Sinai, Inst Immunol, New York, NY 10029 USA

[4] Univ Calif Santa Cruz, Inst Biol Stem Cells, Dept Biomol Engn, Santa Cruz, CA 95064 USA

[5] Natl Univ Singapore, Yong Loo Lin Sch Med, Expt Fetal Med Grp, Singapore 119228, Singapore

[6] KK Womens & Childrens Hosp, Reprod Med, Singapore 229899, Singapore

[7] Duke NUS Grad Med Sch, Singapore & Canc & Stem Cell Biol Program, Singapore 169857, Singapore

[8] Univ Zurich, Inst Expt Immunol, CH-8057 Zurich, Switzerland

[9] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China

来源：

IMMUNITY | 2015年 / 42卷 / 04期

关键词：

HEMATOPOIETIC STEM-CELLS; MOUSE YOLK-SAC; CIRCULATING MONOCYTES; ALVEOLAR MACROPHAGES; STEADY-STATE; GM-CSF; DIFFERENTIATION; MYB; SYSTEM; BLOOD;

D O I：

10.1016/j.immuni.2015.03.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although classified as hematopoietic cells, tissue-resident macrophages (MFs) arise from embryonic precursors that seed the tissues prior to birth to generate a self-renewing population, which is maintained independently of adult hematopoiesis. Here we reveal the identity of these embryonic precursors using an in utero MF-depletion strategy and fate-mapping of yolk sac (YS) and fetal liver (FL) hematopoiesis. We show that YS MFs are the main precursors of microglia, while most other MFs derive from fetal monocytes (MOs). Both YS MFs and fetal MOs arise from erythro-myeloid progenitors (EMPs) generated in the YS. In the YS, EMPs gave rise to MFs without monocytic intermediates, while EMP seeding the FL upon the establishment of blood circulation acquired c-Myb expression and gave rise to fetal MOs that then seeded embryonic tissues and differentiated into MFs. Thus, adult tissue-resident MFs established from hematopoietic stem cell-independent embryonic precursors arise from two distinct developmental programs.

引用

页码：665 / 678

页数：14

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