Molecular mechanisms of host cell invasion by Trypanosoma cruzi

被引：65
作者：
Epting, Conrad L. [1 ]
Coates, Bria M. [1 ]
Engman, David M. [2 ,3 ]
机构：
[1] Northwestern Univ, Dept Pediat, Chicago, IL 60611 USA
[2] Northwestern Univ, Dept Pathol, Chicago, IL 60611 USA
[3] Northwestern Univ, Dept Microbiol Immunol, Chicago, IL 60611 USA
来源：
EXPERIMENTAL PARASITOLOGY | 2010年 / 126卷 / 03期
基金：
美国国家卫生研究院;
关键词：
Trypanosoma cruzi; Invasion; Lysosome; Microtubules; Signaling; CHRONIC CHAGAS-DISEASE; CA2+ SIGNALING ACTIVITY; GPI-ANCHORED PROTEINS; MAMMALIAN-CELLS; METACYCLIC TRYPOMASTIGOTES; CYSTEINE PROTEINASE; SURFACE-MOLECULE; TRANS-SIALIDASE; LIFE-CYCLE; IN-VITRO;
D O I：
10.1016/j.exppara.2010.06.023
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
The protozoan parasite Trypanosoma cruzi, the etiologic agent of Chagas disease, is an obligate intracellular protozoan pathogen. Overlapping mechanisms ensure successful infection, yet the relationship between these cellular events and clinical disease remains obscure. This review explores the process of cell invasion from the perspective of cell surface interactions, intracellular signaling, modulation of the host cytoskeleton and endosomal compartment, and the intracellular innate immune response to infection. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：283 / 291
页数：9
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