Reproductive biology and IVF: ovarian stimulation and luteal phase consequences

被引:166
作者
Fauser, BCJM
Devroey, P
机构
[1] Erasmus MC, Ctr Reprod Med, NL-3015 GD Rotterdam, Netherlands
[2] Vrije Univ Brussels, Univ Hosp, Ctr Reprod Med, Brussels, Belgium
关键词
D O I
10.1016/S1043-2760(03)00075-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Most clinicians working in in vitro fertilization (IVF) centers worldwide have taken for granted for more than a decade the paradigm of so-called 'controlled' ovarian hyperstimulation, using maximum stimulation by exogenous gonadotropins, together with the gonadotropin-releasing hormone (GnRH) agonist long-protocol. Potential detrimental effects of this approach with regard to oocyte quality, corpus luteum function and endometrial receptivity have been largely ignored. These factors might by themselves have a major impact on IVF outcome and should therefore be considered seriously. The recent introduction of GnRH antagonists along with the current emphasis on the need for transfer of a reduced number of embryos enables a careful re-evaluation of current IVF strategies. We can now render stimulation protocols simpler, starting with a spontaneous menstrual cycle, allowing for more subtle interference with single dominant follicle selection. Here, we discuss recent approaches to ovarian stimulation, the induction of oocyte maturation, and effects of these altered follicular phase interventions on corpus luteum function following ovarian stimulation.
引用
收藏
页码:236 / 242
页数:7
相关论文
共 67 条
  • [41] Jones BA, 1996, NEW FOREST, V11, P1
  • [42] Differentiating clinical profiles: predicting good responders, poor responders, and hyperresponders
    Kligman, I
    Rosenwaks, Z
    [J]. FERTILITY AND STERILITY, 2001, 76 (06) : 1185 - 1190
  • [43] Conception to ongoing pregnancy: the 'black box' of early pregnancy loss
    Macklon, NS
    Geraedts, JPM
    Fauser, BCJM
    [J]. HUMAN REPRODUCTION UPDATE, 2002, 8 (04) : 333 - 343
  • [44] Regulation of follicle development and novel approaches to ovarian stimulation for IVF
    Macklon, NS
    Fauser, BCJM
    [J]. HUMAN REPRODUCTION UPDATE, 2000, 6 (04) : 307 - 312
  • [45] THE DEPENDENCY OF FOLLICULOGENESIS AND CORPUS-LUTEUM FUNCTION ON PULSATILE GONADOTROPIN-SECRETION IN CYCLING WOMEN USING A GONADOTROPIN-RELEASING-HORMONE ANTAGONIST AS A PROBE
    MAIS, V
    KAZER, RR
    CETEL, NS
    RIVIER, J
    VALE, W
    YEN, SSC
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1986, 62 (06) : 1250 - 1255
  • [46] One versus two embryo transfer after IVF and ICSI:: a randomized study
    Martikainen, H
    Tiitinen, A
    Tomás, C
    Tapanainen, J
    Orava, M
    Tuomivaara, L
    Vilska, S
    Hydén-Granskog, C
    Hovatta, O
    [J]. HUMAN REPRODUCTION, 2001, 16 (09) : 1900 - 1903
  • [47] Assisted reproductive technology in Europe, 1998. Results generated from European registers by ESHRE
    Nygren, KG
    Andersen, AN
    [J]. HUMAN REPRODUCTION, 2001, 16 (11) : 2459 - 2471
  • [48] INDUCTION OF OVULATION FOR ASSISTED REPRODUCTION PROGRAMS
    OEHNINGER, S
    HODGEN, GD
    [J]. BAILLIERES CLINICAL OBSTETRICS AND GYNAECOLOGY, 1990, 4 (03): : 541 - 573
  • [49] A PROSPECTIVE, RANDOMIZED, ASSESSOR-BLIND, MULTICENTER STUDY COMPARING RECOMBINANT AND URINARY FOLLICLE-STIMULATING-HORMONE (PUREGON VERSUS METRODIN) IN IN-VITRO FERTILIZATION
    OUT, HJ
    MANNAERTS, BMJL
    DRIESSEN, SGAJ
    COELINGHBENNINK, HJT
    [J]. HUMAN REPRODUCTION, 1995, 10 (10) : 2534 - 2540
  • [50] A randomized, double-blind clinical trial using fixed daily doses of 100 or 200 IU of recombinant FSH in ICSI cycles
    Out, HJ
    David, I
    Ron-El, R
    Friedler, S
    Shalev, E
    Geslevich, J
    Dor, J
    Shulman, A
    Ben-Rafael, Z
    Fisch, B
    Dirnfeld, M
    [J]. HUMAN REPRODUCTION, 2001, 16 (06) : 1104 - 1109