Interleukin-15 in obesity and metabolic dysfunction: current understanding and future perspectives

被引：38
作者：
Duan, Y. [1 ,2 ,3 ,4 ,5 ]
Li, F. [1 ,2 ,3 ,4 ,6 ]
Wang, W. [7 ]
Guo, Q. [1 ,2 ,3 ,4 ,5 ]
Wen, C. [7 ]
Li, Y. [1 ,2 ,3 ,4 ,5 ]
Yin, Y. [1 ,2 ,3 ,4 ,7 ]
机构：
[1] Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, Changsha, Hunan, Peoples R China
[2] Natl Engn Lab Pollut Control & Waste Utilizat Liv, Changsha, Hunan, Peoples R China
[3] Hunan Prov Engn Res Ctr Hlth Livestock & Poult, Changsha, Hunan, Peoples R China
[4] Minist Agr, Sci Observing & Expt Stn Anim Nutr & Feed Sci Sou, Changsha, Hunan, Peoples R China
[5] Univ Chinese Acad Sci, Beijing, Peoples R China
[6] CICSAP, Hunan Coinnovat Ctr Safety Anim Prod, Changsha, Hunan, Peoples R China
[7] Hunan Normal Univ, Sch Biol, Lab Anim Nutr & Human Hlth, Changsha, Hunan, Peoples R China
来源：
OBESITY REVIEWS | 2017年 / 18卷 / 10期
关键词：
Interleukin-15; obesity; type 2 diabetes mellitus; IMPROVES GLUCOSE-HOMEOSTASIS; SUBCUTANEOUS ADIPOSE-TISSUE; SKELETAL-MUSCLE; GENE-EXPRESSION; MITOCHONDRIAL DYSFUNCTION; PPAR-DELTA; IL-15; ADIPONECTIN; ALPHA; ASSOCIATION;
D O I：
10.1111/obr.12567
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Obesity rises rapidly and is a major health concern for modern people. Importantly, it is a major risk factor in the development of numerous chronic diseases such as type 2 diabetes mellitus (T2DM). Recently, interleukin (IL)-15 has attracted considerable attention as a potential regulator for the prevention and/or treatment of obesity and T2DM. The beneficial effects include increased loss of fat mass and body weight, improved lipid and glucose metabolism, reduced white adipose tissue inflammation, enhanced mitochondrial function, alterations in the composition of muscle fibres and gut bacterial and attenuated endoplasmic reticulum stress. Although these beneficial effects are somewhat controversial, IL-15, exogenously delivered or endogenously produced, may be a promising target in the prevention and treatment of obesity and T2DM.
引用
收藏
页码：1147 / 1158
页数：12
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